دورية أكاديمية
Assessing pulmonary perfusion in emphysema: automated quantification of perfused blood volume in dual-energy CTPA.
| العنوان: | Assessing pulmonary perfusion in emphysema: automated quantification of perfused blood volume in dual-energy CTPA. |
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| المؤلفون: | Meinel FG; Department of Clinical Radiology, Ludwig Maximilians-University, Munich, Germany. felix.meinel@med.uni-muenchen.de, Graef A, Thieme SF, Bamberg F, Schwarz F, Sommer WH, Helck AD, Neurohr C, Reiser MF, Johnson TR |
| المصدر: | Investigative radiology [Invest Radiol] 2013 Feb; Vol. 48 (2), pp. 79-85. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0045377 Publication Model: Print Cited Medium: Internet ISSN: 1536-0210 (Electronic) Linking ISSN: 00209996 NLM ISO Abbreviation: Invest Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Philadelphia. |
| مواضيع طبية MeSH: | Tomography, X-Ray Computed*, Perfusion Imaging/*methods , Pulmonary Emphysema/*diagnostic imaging , Pulmonary Emphysema/*physiopathology, Adult ; Aged ; Aged, 80 and over ; Angiography/methods ; Blood Volume ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies |
| مستخلص: | Objectives: The objective of this study was to determine whether automated quantification of lung perfused blood volume (PBV) in dual-energy computed tomographic pulmonary angiography (DE-CTPA) can be used to assess the severity and regional distribution of pulmonary hypoperfusion in emphysema. Materials and Methods: We retrospectively analyzed 40 consecutive patients (mean age, 67 [13] years) with pulmonary emphysema, who have no cardiopulmonary comorbidities, and a DE-CTPA negative for pulmonary embolism. Automated quantification of global and regional pulmonary PBV was performed using the syngo Dual Energy application (Siemens Healthcare). Similarly, the global and regional degrees of parenchymal hypodensity were assessed automatically as the percentage of voxels with a computed tomographic density less than -900 Hounsfield unit. Emphysema severity was rated visually, and pulmonary function tests were obtained by chart review, if available. Results: Global PBV generated by automated quantification of pulmonary PBV in the DE-CTPA data sets showed a moderately strong but highly significant negative correlation with residual volume in percentage of the predicted residual volume (r = -0.62; P = 0.002; n = 23) and a positive correlation with forced expiratory volume in 1 second in percentage of the predicted forced expiratory volume in 1 second (r = 0.67; P < 0.001; n = 23). Global PBV values strongly correlated with diffusing lung capacity for carbon monoxide (r = 0.80; P < 0.001; n = 15). Pulmonary PBV values decreased with visual emphysema severity (r = -0.46, P = 0.003, n = 40). Moderate negative correlations were found between global PBV values and parenchymal hypodensity both in a per-patient (r = -0.63; P < 0.001; n = 40) and per-region analyses (r = -0.62; P < 0.001; n = 40). Conclusions: Dual-energy computed tomographic pulmonary angiography allows simultaneous assessment of lung morphology, parenchymal density, and pulmonary PBV. In patients with pulmonary emphysema, automated quantification of pulmonary PBV in DE-CTPA can be used for a quick, reader-independent estimation of global and regional pulmonary perfusion, which correlates with several lung function parameters. |
| تواريخ الأحداث: | Date Created: 20130105 Date Completed: 20130711 Latest Revision: 20161125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/RLI.0b013e3182778f07 |
| PMID: | 23288014 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-0210 |
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| DOI: | 10.1097/RLI.0b013e3182778f07 |