دورية أكاديمية
[Effects of telmisartan on the level of Aβ1-42, interleukin-1β, tumor necrosis factor α and cognition in hypertensive patients with Alzheimer's disease].
| العنوان: | [Effects of telmisartan on the level of Aβ1-42, interleukin-1β, tumor necrosis factor α and cognition in hypertensive patients with Alzheimer's disease]. |
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| المؤلفون: | Li W; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, China., Zhang JW, Lu F, Ma MM, Wang JQ, Suo AQ, Bai YY, Liu HQ |
| المصدر: | Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2012 Oct 23; Vol. 92 (39), pp. 2743-6. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 7511141 Publication Model: Print Cited Medium: Print ISSN: 0376-2491 (Print) Linking ISSN: 03762491 NLM ISO Abbreviation: Zhonghua Yi Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhonghua yi xue hui Original Publication: Beijing : Zhonghua yi xue hui. |
| مواضيع طبية MeSH: | Alzheimer Disease/*psychology , Antihypertensive Agents/*therapeutic use , Benzimidazoles/*therapeutic use , Benzoates/*therapeutic use , Cognition/*drug effects , Hypertension/*psychology, Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Alzheimer Disease/drug therapy ; Amlodipine/therapeutic use ; Amyloid beta-Peptides/cerebrospinal fluid ; Female ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Interleukin-1beta/cerebrospinal fluid ; Male ; Middle Aged ; PPAR gamma/metabolism ; Peptide Fragments/cerebrospinal fluid ; Telmisartan ; Tumor Necrosis Factor-alpha/cerebrospinal fluid |
| مستخلص: | Objective: To explore the effects of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor γ-stimulating activity, on the levels of Aβ1-42, interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) and cognition in elderly hypertensive patients with Alzheimer's disease (AD). Methods: A total of 48 patients with probable AD and essential hypertension were randomly assigned into telmisartan group (n = 24, 40 - 80 mg qd) or amlodipine group (n = 24, 5 - 10 mg qd) for 6 months at Henan Provincial People's Hospital during 2008 - 2011. Cognitive evaluations were assessed at pre-treatment and 24 weeks post-treatment by clinical assessment, rating scales and neuropsychological tests while the cerebrospinal fluid (CSF) levels of Aβ1-42, IL-1β and TNF-α by enzyme-linked immunosorbent assay (ELISA). Results: After 6 months, mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) significantly decreased compared with baseline values to a similar extent in both groups. No significant differences existed between two groups in SBP or DBP. The patients displayed significantly higher Aβ1-42 and greatly lower levels of IL-1β and TNF-α in the telmisartan group versus the amlodipine group (P < 0.05). At 24 weeks, the patients in the telmisartan group had better mini-mental state examination (MMSE) (22.0 ± 3.4) and Alzheimer's disease assessment scale-cognitive subscale (ADAS-cog) (15 ± 5) scales scores than those taking amlodipine (MMSE (19.5 ± 2.8) and ADAS-cog (18 ± 5). Patients treated with telmisartan had better improvement on the MMSE (P < 0.05) and ADAS-cog (P < 0.05) scales compared with the amlodipine group by the end of study week 24. Conclusion: Telmisartan may delay the decreased level of Aβ1-42 and reduce the levels IL-1β and TNF-α in CSF so as to improve the cognitive function of elderly hypertensive patients with AD. With additional benefits in comparison with common antihypertensive drugs, it may offer a novel therapeutic strategy of AD. |
| المشرفين على المادة: | 0 (Amyloid beta-Peptides) 0 (Antihypertensive Agents) 0 (Benzimidazoles) 0 (Benzoates) 0 (Interleukin-1beta) 0 (PPAR gamma) 0 (Peptide Fragments) 0 (Tumor Necrosis Factor-alpha) 0 (amyloid beta-protein (1-42)) 1J444QC288 (Amlodipine) U5SYW473RQ (Telmisartan) |
| تواريخ الأحداث: | Date Created: 20130108 Date Completed: 20131125 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| PMID: | 23290159 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0376-2491 |
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