دورية أكاديمية
أعرض في EDS

A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations.

التفاصيل البيبلوغرافية
العنوان: A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations.
المؤلفون: Karakas M; Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany., Baumert J, Kleber ME, Thorand B, Dallmeier D, Silbernagel G, Grammer TB, Rottbauer W, Meisinger C, Illig T, März W, Koenig W
المصدر: PloS one [PLoS One] 2012; Vol. 7 (12), pp. e51441. Date of Electronic Publication: 2012 Dec 28.
نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Genetic Predisposition to Disease* , Genome-Wide Association Study*, ABO Blood-Group System/*genetics , Cardiovascular Diseases/*etiology , E-Selectin/*genetics , Polymorphism, Single Nucleotide/*genetics, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Cardiovascular Diseases/epidemiology ; Disease Models, Animal ; Female ; Genotype ; Germany/epidemiology ; Humans ; Male ; Mice ; Middle Aged ; Phenotype ; Risk Factors ; Young Adult
مستخلص: Background: Elevated soluble (s) E-selectin levels have been associated with various cardiovascular diseases. Recently, genetic variants in the ABO blood group have been related to E-selectin levels in a small cohort of patients with type 1 diabetes. We evaluated whether this association is reproducible in two large samples of Caucasians.
Methodology/ Principal Findings: Data of the present study was drawn from the population-based MONICA/KORA Augsburg study (n = 1,482) and the patients-based LURIC study (n = 1,546). A high-density genotyping array (50K IBC Chip) containing single-nucleotide polymorphisms (SNPs) from E-selectin candidate genes selected on known biology of E-selectin metabolism, mouse genetic studies, and human genetic association studies, was used for genotyping. Linear regression analyses with adjustment for age and sex (and survey in KORA) were applied to assess associations between gene variants and sE-selectin concentrations. A number of 12 SNPs (in KORA) and 13 SNPs (in LURIC), all from the ABO blood group gene, were significantly associated with the log-transformed concentration of E-selectin. The strongest association was observed for rs651007 with a change of log-transformed sE-selectin per one copy of the minor allele of -0.37 ng/ml (p = 1.87×10(-103)) in KORA and -0.35 ng/ml (p = 5.11×10(-84)) in LURIC. Inclusion of rs651007 increased the explained sE-selectin variance by 0.256 in KORA and 0.213 in LURIC. All SNPs had minor allele frequencies above 20% showing a substantial gene variation.
Conclusions/ Significance: Our findings in two independent samples indicate that the genetic variants at the ABO locus affect sE-selectin levels. Since distinct genome-wide association studies linked the ABO gene with myocardial infarction (MI) in the presence of coronary atherosclerosis and with coronary artery disease, these findings may not only enhance our understanding of adhesion molecule biology, but may also provide a focus for several novel research avenues.
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المشرفين على المادة: 0 (ABO Blood-Group System)
0 (E-Selectin)
تواريخ الأحداث: Date Created: 20130110 Date Completed: 20130717 Latest Revision: 20211021
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC3532506
DOI: 10.1371/journal.pone.0051441
PMID: 23300549
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0051441