دورية أكاديمية
أعرض في EDS

Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease.

التفاصيل البيبلوغرافية
العنوان: Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease.
المؤلفون: Hoh RA; Department of Biology, Stanford University, Stanford, CA, USA., Stowe TR, Turk E, Stearns T
المصدر: PloS one [PLoS One] 2012; Vol. 7 (12), pp. e52166. Date of Electronic Publication: 2012 Dec 31.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Gene Expression Profiling* , Genetic Diseases, Inborn*, Biomarkers/*metabolism , Centrosome/*metabolism , Cilia/*metabolism , Epithelial Cells/*metabolism , Trachea/*metabolism, Animals ; Cell Differentiation ; Cells, Cultured ; Epithelial Cells/cytology ; Female ; Fluorescent Antibody Technique, Indirect ; Forkhead Transcription Factors/physiology ; Humans ; Male ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Transgenic ; NIH 3T3 Cells ; Oligonucleotide Array Sequence Analysis ; Trachea/cytology ; Transcriptional Activation
مستخلص: Defects in the centrosome and cilium are associated with a set of human diseases having diverse phenotypes. To further characterize the components that define the function of these organelles we determined the transcriptional profile of multiciliated tracheal epithelial cells. Cultures of mouse tracheal epithelial cells undergoing differentiation in vitro were derived from mice expressing GFP from the ciliated-cell specific FOXJ1 promoter (FOXJ1:GFP). The transcriptional profile of ciliating GFP+ cells from these cultures was defined at an early and a late time point during differentiation and was refined by subtraction of the profile of the non-ciliated GFP- cells. We identified 649 genes upregulated early, when most cells were forming basal bodies, and 73 genes genes upregulated late, when most cells were fully ciliated. Most, but not all, of known centrosome proteins are transcriptionally upregulated early, particularly Plk4, a master regulator of centriole formation. We found that three genes associated with human disease states, Mdm1, Mlf1, and Dyx1c1, are upregulated during ciliogenesis and localize to centrioles and cilia. This transcriptome for mammalian multiciliated epithelial cells identifies new candidate centrosome and cilia proteins, highlights similarities between components of motile and primary cilia, and identifies new links between cilia proteins and human disease.
References: Nature. 1995 Dec 7;378(6557):638-40. (PMID: 8524401)
J Cell Sci. 2006 Mar 15;119(Pt 6):1165-74. (PMID: 16507594)
Biol Cell. 2011 Mar;103(3):109-30. (PMID: 21275904)
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6998-7003. (PMID: 19369198)
Nature. 2006 Mar 9;440(7081):224-7. (PMID: 16525475)
Adv Exp Med Biol. 2010;664:223-32. (PMID: 20238021)
Curr Opin Cell Biol. 2006 Feb;18(1):74-8. (PMID: 16361091)
BMC Cell Biol. 2009 Mar 02;10:17. (PMID: 19254375)
Leukemia. 2000 Oct;14(10):1757-65. (PMID: 11021751)
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3380-5. (PMID: 18299575)
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2817-22. (PMID: 10077594)
Cell. 2004 May 14;117(4):527-39. (PMID: 15137945)
Am J Respir Cell Mol Biol. 2007 Aug;37(2):169-85. (PMID: 17413031)
Curr Biol. 2009 Jul 14;19(13):R526-35. (PMID: 19602418)
Biol Psychiatry. 2013 Mar 15;73(6):583-90. (PMID: 23036959)
Am J Physiol Lung Cell Mol Physiol. 2002 Dec;283(6):L1315-21. (PMID: 12388377)
Annu Rev Genomics Hum Genet. 2006;7:125-48. (PMID: 16722803)
Curr Biol. 2007 Sep 4;17(17):1465-72. (PMID: 17689959)
Trends Genet. 2009 Nov;25(11):501-10. (PMID: 19850369)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
J Cell Biol. 2010 Nov 15;191(4):721-9. (PMID: 21059850)
Dev Cell. 2007 Aug;13(2):190-202. (PMID: 17681131)
Biol Cell. 1991;72(1-2):31-8. (PMID: 1756310)
Development. 2005 Apr;132(8):1923-34. (PMID: 15790967)
EMBO J. 2009 Jul 22;28(14):2066-76. (PMID: 19536135)
Nat Genet. 2008 Dec;40(12):1445-53. (PMID: 19011630)
Trends Genet. 2006 Sep;22(9):491-500. (PMID: 16860433)
J Cell Sci. 2011 Aug 1;124(Pt 15):2622-30. (PMID: 21750193)
Oncogene. 2002 Sep 9;21(40):6175-83. (PMID: 12214247)
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D535-9. (PMID: 16381927)
J Biol Chem. 2000 Aug 4;275(31):24106-14. (PMID: 10807915)
EMBO J. 2011 Apr 20;30(8):1520-35. (PMID: 21399614)
Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L25-31. (PMID: 20971803)
Biol Cell. 2011 Jun;103(6):249-70. (PMID: 21728999)
Science. 2009 Aug 28;325(5944):1131-4. (PMID: 19628819)
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11553-8. (PMID: 12954984)
Mol Ther. 2003 Oct;8(4):637-45. (PMID: 14529837)
Curr Biol. 2003 Jan 21;13(2):R50-2. (PMID: 12546802)
Methods Mol Biol. 2009;577:67-79. (PMID: 19718509)
Nat Genet. 2006 Sep;38(9):961-2. (PMID: 16940995)
Science. 2007 Oct 12;318(5848):245-50. (PMID: 17932292)
Mol Cell Proteomics. 2007 Aug;6(8):1299-317. (PMID: 17494944)
Brain Res Bull. 2007 Mar 15;71(5):508-14. (PMID: 17259020)
Cell. 2000 Sep 29;103(1):127-40. (PMID: 11051553)
Hum Mol Genet. 2008 Dec 15;17(24):3929-41. (PMID: 18805803)
Curr Biol. 2008 Jan 22;18(2):136-41. (PMID: 18207742)
Genome Biol. 2006;7(12):R126. (PMID: 17187676)
Bioinformatics. 2004 Dec 12;20(18):3705-6. (PMID: 15297296)
Curr Biol. 2005 May 24;15(10):935-41. (PMID: 15916950)
J Cell Sci. 2007 Dec 15;120(Pt 24):4321-31. (PMID: 18042621)
Hum Mol Genet. 2006 May 15;15(10):1659-66. (PMID: 16600991)
J Cell Sci. 2007 Feb 1;120(Pt 3):478-91. (PMID: 17227795)
Hum Mol Genet. 1997 Dec;6(13):2205-12. (PMID: 9361024)
Methods Mol Biol. 2006;346:479-89. (PMID: 16957309)
Trends Genet. 2011 Aug;27(8):307-15. (PMID: 21680046)
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3703-7. (PMID: 15738400)
J Cell Biol. 2005 Jul 4;170(1):103-13. (PMID: 15998802)
Neurobiol Dis. 2010 May;38(2):173-80. (PMID: 19616627)
J Clin Invest. 2009 Mar;119(3):428-37. (PMID: 19252258)
Curr Opin Cell Biol. 2009 Feb;21(1):14-9. (PMID: 19196504)
J Cell Biol. 2010 Nov 15;191(4):731-9. (PMID: 21059844)
Nature. 2003 Dec 4;426(6966):570-4. (PMID: 14654843)
Nat Genet. 2004 May;36(5):462-70. (PMID: 15107855)
Mol Cell Biol. 2008 Jan;28(1):422-34. (PMID: 17967869)
J Cell Sci. 1990 May;96 ( Pt 1):27-33. (PMID: 2373742)
J Cell Biol. 2007 Jan 15;176(2):173-82. (PMID: 17227892)
Nature. 1995 Dec 7;378(6557):578-83. (PMID: 8524390)
Nat Cell Biol. 2005 Feb;7(2):115-25. (PMID: 15665853)
PLoS Genet. 2005 Oct;1(4):e53. (PMID: 16254602)
J Cell Biol. 2000 Nov 13;151(4):837-46. (PMID: 11076968)
Neuroscience. 2006 Dec 1;143(2):515-22. (PMID: 16989952)
Genet Med. 2009 Jun;11(6):386-402. (PMID: 19421068)
J Cell Sci. 2012 Oct 15;125(Pt 20):4770-9. (PMID: 22797915)
Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L650-7. (PMID: 12818891)
Curr Biol. 2009 May 26;19(10):816-26. (PMID: 19427217)
Curr Biol. 2005 Dec 20;15(24):2199-207. (PMID: 16326102)
Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):140-7. (PMID: 18521840)
Nat Rev Genet. 2010 May;11(5):331-44. (PMID: 20395968)
J Cell Biol. 2007 Jul 2;178(1):31-42. (PMID: 17606865)
Eur J Hum Genet. 2006 Jun;14(6):681-9. (PMID: 16721404)
Cell. 2006 Jun 30;125(7):1375-86. (PMID: 16814722)
Physiol Genomics. 2008 Jan 17;32(2):198-206. (PMID: 17971504)
J Cell Sci. 2007 Jan 1;120(Pt 1):7-15. (PMID: 17182899)
Cell. 2009 Jan 9;136(1):188-188.e1. (PMID: 19135899)
Nat Cell Biol. 2009 Mar;11(3):278-85. (PMID: 19182792)
J Cell Biol. 1999 Nov 29;147(5):969-80. (PMID: 10579718)
Cell. 2006 May 5;125(3):549-62. (PMID: 16678098)
Nature. 2009 May 7;459(7243):98-102. (PMID: 19305393)
Oncogene. 2002 Sep 9;21(40):6222-7. (PMID: 12214252)
Int Rev Cytol. 2004;234:101-41. (PMID: 15066374)
PLoS One. 2012;7(4):e35618. (PMID: 22558177)
Nat Genet. 2008 Dec;40(12):1454-60. (PMID: 19011629)
J Cell Sci. 2010 Feb 15;123(Pt 4):505-9. (PMID: 20144998)
Cell. 2009 Nov 13;139(4):663-78. (PMID: 19914163)
Nat Cell Biol. 2005 Nov;7(11):1140-6. (PMID: 16244668)
Mol Cell Proteomics. 2008 Mar;7(3):499-508. (PMID: 18029348)
PLoS One. 2011;6(6):e20580. (PMID: 21698230)
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12611-6. (PMID: 18719094)
Nat Cell Biol. 2011 Oct 03;13(10):1154-60. (PMID: 21968988)
Mol Cell Proteomics. 2002 Jun;1(6):451-65. (PMID: 12169685)
Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):967-76. (PMID: 19191256)
Curr Biol. 2005 Jun 21;15(12):1090-8. (PMID: 15964273)
Development. 2009 Dec;136(23):4021-31. (PMID: 19906869)
Genes Cells. 2006 Dec;11(12):1317-35. (PMID: 17121541)
J Cell Biol. 2010 Oct 18;191(2):331-46. (PMID: 20956381)
Nature. 2010 Oct 7;467(7316):714-8. (PMID: 20852615)
Cell. 2004 May 14;117(4):541-52. (PMID: 15137946)
Mol Biol Cell. 2005 Mar;16(3):1095-107. (PMID: 15616186)
معلومات مُعتمدة: R01 GM052022 United States GM NIGMS NIH HHS; T32 CA009302 United States CA NCI NIH HHS; GM52022 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Biomarkers)
0 (FOXJ1 protein, mouse)
0 (Forkhead Transcription Factors)
تواريخ الأحداث: Date Created: 20130110 Date Completed: 20130717 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3534086
DOI: 10.1371/journal.pone.0052166
PMID: 23300604
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0052166