دورية أكاديمية
The retinal disease screening study: prospective comparison of nonmydriatic fundus photography and optical coherence tomography for detection of retinal irregularities.
| العنوان: | The retinal disease screening study: prospective comparison of nonmydriatic fundus photography and optical coherence tomography for detection of retinal irregularities. |
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| المؤلفون: | Ouyang Y; Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA., Heussen FM, Keane PA, Sadda SR, Walsh AC |
| المصدر: | Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2013 Feb 19; Vol. 54 (2), pp. 1460-8. Date of Electronic Publication: 2013 Feb 19. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Electronic Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Brookline Ma : Association For Research In Vision And Ophthalmology (Arvo) Original Publication: St. Louis, Mosby. |
| مواضيع طبية MeSH: | Fluorescein Angiography/*methods , Retina/*pathology , Retinal Diseases/*diagnosis , Tomography, Optical Coherence/*methods, Adolescent ; Adult ; Aged ; Female ; Fundus Oculi ; Humans ; Male ; Middle Aged ; Prospective Studies ; Reproducibility of Results ; Young Adult |
| مستخلص: | Purpose: To compare the sensitivity of volume scanning with optical coherence tomography (OCT) to nonmydriatic color fundus photography (FP) for the detection of retinal irregularities in asymptomatic populations. Methods: Asymptomatic subjects without known ocular disease were recruited over a 6-month period. For each eye, two undilated 45° fundus images and four undilated volume OCT image sets covering the macula and optic nerve were obtained. Color images were evaluated for irregularities both inside and outside the area covered by OCT. OCT image sets were evaluated for internal limiting membrane irregularities, abnormal retinal thickness, hyper/hyporeflective features, and photoreceptor/retinal pigment epithelium (RPE) irregularities. Detection sensitivities were compared and false-negative cases were analyzed. Results: A total of 284 eyes (144 subjects) were included, with a mean age of 38.1 years (range 18-77). Among 253 eyes (135 subjects) with gradable images from both FP and OCTs, the detection sensitivities for OCT were higher (96.2% infield and 85.7% in full field) than for FP (19.9% infield and 43.8% in full field) for all irregularities evaluated in the study (including epiretinal irregularities, abnormal retinal thickness, intraretinal hyperreflective/hyporeflective features, and photoreceptor/RPE irregularities). Overall, the presence of definite irregularities on either fundus imaging or OCT by eye in this asymptomatic population was 42.6% (121/284), with 39.4% (112/284) of eyes having RPE irregularities such as drusen. Conclusions: For detection of a variety of retinal irregularities evaluated in the current study, volume OCT scanning was more sensitive than nonmydriatic retinal photography in our asymptomatic individuals. OCT detected clinically relevant disease features, such as subretinal fluid, that were missed by FP, and had a lower ungradable image rate. It is likely that OCT will be added to photography screening in the near future for chorioretinal disease. |
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| معلومات مُعتمدة: | 1286 United Kingdom DH_ Department of Health; P30 EY003040 United States EY NEI NIH HHS; EY03040 United States EY NEI NIH HHS; R01 EY014375 United States EY NEI NIH HHS; R01EY014375 United States EY NEI NIH HHS |
| تواريخ الأحداث: | Date Created: 20130117 Date Completed: 20130409 Latest Revision: 20211021 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3597191 |
| DOI: | 10.1167/iovs.12-10727 |
| PMID: | 23322579 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1552-5783 |
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| DOI: | 10.1167/iovs.12-10727 |