دورية أكاديمية
Ovariectomy causes overexpression of renal Na(+),K(+)-ATPase and sodium-sensitive hypertension in adult Wistar rats.
| العنوان: | Ovariectomy causes overexpression of renal Na(+),K(+)-ATPase and sodium-sensitive hypertension in adult Wistar rats. |
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| المؤلفون: | Di Ciano LA; Laboratorio de Riñón, Instituto de Investigaciones Médicas A Lanari, Buenos Aires University , Buenos Aires , Argentina., Azurmendi PJ, Toledo JE, Oddo EM, Zotta E, Ochoa F, Arrizurieta EE, Ibarra FR |
| المصدر: | Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2013; Vol. 35 (7), pp. 475-83. Date of Electronic Publication: 2013 Jan 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9305929 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6006 (Electronic) Linking ISSN: 10641963 NLM ISO Abbreviation: Clin Exp Hypertens Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, N.Y. : Marcel Dekker, Inc., c1993- |
| مواضيع طبية MeSH: | Hypertension/*enzymology , Hypertension/*etiology , Kidney/*enzymology , Ovariectomy/*adverse effects , Sodium-Potassium-Exchanging ATPase/*metabolism, Animals ; Blood Pressure ; Female ; Hypertension/physiopathology ; Loop of Henle/enzymology ; Natriuresis ; Ovary/physiology ; Rats ; Rats, Wistar ; Renal Plasma Flow ; Sodium, Dietary/administration & dosage |
| مستخلص: | We investigated the effect of ovariectomy(oVx) on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated Na(+),K(+)-ATPase α1 subunit (t-d-NKA) in normotensive Wistar rats under a normal sodium (NS, 0.24%) or high sodium (HS, 1%) intake versus intact female (IF). On NS intake, t-d-NKA was higher in oVx rats and overexpressed in the thick ascending limbs (P < .01 vs. IF) and renal plasma flow was increased. On HS intake, oVx rats maintained a greater dephosphorylated NKA, excreted less sodium, and developed arterial hypertension (134 ± 4 vs. IF 112 ± 5 mm Hg, P < .05). Sodium load caused salt-sensitive hypertension in oVx Wistar rats. |
| المشرفين على المادة: | 0 (Sodium, Dietary) EC 3.6.1.- (Atp1a1 protein, rat) EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase) |
| تواريخ الأحداث: | Date Created: 20130119 Date Completed: 20140602 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3109/10641963.2012.758273 |
| PMID: | 23327671 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1525-6006 |
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| DOI: | 10.3109/10641963.2012.758273 |