دورية أكاديمية
Balance of Treg vs. T-helper cells in the transition from symptomless to lesional psoriatic skin.
| العنوان: | Balance of Treg vs. T-helper cells in the transition from symptomless to lesional psoriatic skin. |
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| المؤلفون: | Keijsers RR; Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. r.keijsers@derma.umcn.nl, van der Velden HM, van Erp PE, de Boer-van Huizen RT, Joosten I, Koenen HJ, van de Kerkhof PC |
| المصدر: | The British journal of dermatology [Br J Dermatol] 2013 Jun; Vol. 168 (6), pp. 1294-302. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0004041 Publication Model: Print Cited Medium: Internet ISSN: 1365-2133 (Electronic) Linking ISSN: 00070963 NLM ISO Abbreviation: Br J Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Oxford : Oxford University Press Original Publication: Oxford [etc.] Published for the British Association of Dermatologists by Blackwell Scientific Publications [etc.] |
| مواضيع طبية MeSH: | Forkhead Transcription Factors/*immunology , Interleukin-17/*immunology , Psoriasis/*immunology , T-Lymphocytes, Helper-Inducer/*immunology , T-Lymphocytes, Regulatory/*immunology, Adult ; Aged ; Case-Control Studies ; Female ; Humans ; Immunohistochemistry ; Male ; Mast Cells/immunology ; Middle Aged ; Psoriasis/pathology ; Severity of Illness Index |
| مستخلص: | Background: In the pathogenesis of psoriasis, proinflammatory T cells are strongly involved in the inflammatory process, where regulatory T-cell (Treg) function is impaired. Objectives: As effective Treg function is associated with a numerical balance between Treg and effector T cells, we wondered whether Treg/T-helper cell ratios may be associated with certain stages of the inflammatory process. We opted for the margin zone model as a dynamic approach. Methods: From nine patients with chronic plaque psoriasis, 3-mm punch biopsies were obtained from the centre and margin of the lesion, perilesional skin and distant uninvolved skin. Skin biopsies of 10 healthy volunteers were included as a control. Samples were analysed using immunohistochemistry and immunofluorescence. Results: In the transition from symptomless to lesional skin, a significant increase of CD3+, CD4+ and Foxp3+ cells was found. In seven of nine patients the ratio of Treg (Foxp3+) vs. CD4+ T cells was higher in the distant uninvolved skin than in the perilesional and lesional skin. Interestingly, the Foxp3/CD4 ratio in the distant uninvolved skin was even higher than in the skin of healthy controls. Notably, we found that most of the interleukin (IL)-17 expression was not related to CD4+ cells, but to mast cells. Conclusions: The relatively high Foxp3/CD4 ratio in symptomless skin of patients with psoriasis suggests an active immune controlling mechanism distant from the psoriatic plaque. In the margin and centre of the plaque the ratio appears skewed towards effector cells associated with inflammation. IL-17, an important driver of the psoriatic process, is mostly related to mast cells, and only sporadically to T cells. (© 2013 The Authors. BJD © 2013 British Association of Dermatologists.) |
| المشرفين على المادة: | 0 (FOXP3 protein, human) 0 (Forkhead Transcription Factors) 0 (Interleukin-17) |
| تواريخ الأحداث: | Date Created: 20130122 Date Completed: 20140227 Latest Revision: 20220409 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/bjd.12236 |
| PMID: | 23330679 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2133 |
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| DOI: | 10.1111/bjd.12236 |