دورية أكاديمية
أعرض في EDS

Link between GIP and osteopontin in adipose tissue and insulin resistance.

التفاصيل البيبلوغرافية
العنوان: Link between GIP and osteopontin in adipose tissue and insulin resistance.
المؤلفون: Ahlqvist E; Department of Clinical Sciences, Diabetes, and Endocrinology, University Hospital Malmö, Lund University, Malmö, Sweden., Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, Pihlajamäki J, Wierup N, Vaag A, Groop L, Lyssenko V
المصدر: Diabetes [Diabetes] 2013 Jun; Vol. 62 (6), pp. 2088-94. Date of Electronic Publication: 2013 Jan 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
أسماء مطبوعة: Publication: Alexandria, VA : American Diabetes Association
Original Publication: [New York, American Diabetes Association]
مواضيع طبية MeSH: Adipose Tissue/*metabolism , Gastric Inhibitory Polypeptide/*pharmacology , Insulin Resistance/*physiology, Adipose Tissue/drug effects ; Adolescent ; Adult ; Aged ; Alleles ; Animals ; Cells, Cultured ; Female ; Humans ; In Vitro Techniques ; Insulin Resistance/genetics ; Male ; Mice ; Middle Aged ; Osteopontin/genetics ; Rats ; Receptors, Gastrointestinal Hormone/genetics ; Receptors, Gastrointestinal Hormone/metabolism ; Young Adult
مستخلص: Low-grade inflammation in obesity is associated with accumulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of local as well as systemic insulin resistance. Since glucose-dependent insulinotropic polypeptide (GIP) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether GIP directly would stimulate OPN expression in adipose tissue and thereby induce insulin resistance. GIP stimulated OPN protein expression in a dose-dependent fashion in rat primary adipocytes. The level of OPN mRNA was higher in adipose tissue of obese individuals (0.13 ± 0.04 vs. 0.04 ± 0.01, P < 0.05) and correlated inversely with measures of insulin sensitivity (r = -0.24, P = 0.001). A common variant of the GIP receptor (GIPR) (rs10423928) gene was associated with a lower amount of the exon 9-containing isoform required for transmembrane activity. Carriers of the A allele with a reduced receptor function showed lower adipose tissue OPN mRNA levels and better insulin sensitivity. Together, these data suggest a role for GIP not only as an incretin hormone but also as a trigger of inflammation and insulin resistance in adipose tissue. Carriers of the GIPR rs10423928 A allele showed protective properties via reduced GIP effects. Identification of this unprecedented link between GIP and OPN in adipose tissue might open new avenues for therapeutic interventions.
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المشرفين على المادة: 0 (Receptors, Gastrointestinal Hormone)
106441-73-0 (Osteopontin)
59392-49-3 (Gastric Inhibitory Polypeptide)
D6H00MV7K8 (gastric inhibitory polypeptide receptor)
تواريخ الأحداث: Date Created: 20130126 Date Completed: 20130802 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3661641
DOI: 10.2337/db12-0976
PMID: 23349498
قاعدة البيانات: MEDLINE
الوصف
تدمد:1939-327X
DOI:10.2337/db12-0976