دورية أكاديمية
أعرض في EDS

Human papillomavirus infection in a male population attending a sexually transmitted infection service.

التفاصيل البيبلوغرافية
العنوان: Human papillomavirus infection in a male population attending a sexually transmitted infection service.
المؤلفون: Álvarez-Argüelles ME; Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, Spain. martaealvarez@gmail.com, Melón S, Junquera ML, Boga JA, Villa L, Pérez-Castro S, de Oña M
المصدر: PloS one [PLoS One] 2013; Vol. 8 (1), pp. e54375. Date of Electronic Publication: 2013 Jan 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Capsid Proteins/*isolation & purification , Oncogene Proteins, Viral/*isolation & purification , Papillomaviridae/*isolation & purification , Papillomavirus E7 Proteins/*isolation & purification , Papillomavirus Infections/*epidemiology, Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Ambulatory Care ; Capsid Proteins/genetics ; Coinfection ; Humans ; Male ; Middle Aged ; Molecular Typing ; Oncogene Proteins, Viral/genetics ; Papillomaviridae/classification ; Papillomaviridae/genetics ; Papillomavirus E7 Proteins/genetics ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/pathology ; Papillomavirus Infections/transmission ; Prevalence ; Spain/epidemiology
مستخلص: Objective: Human Papillomavirus (HPV) infection in men may produce cancer and other major disorders. Men play an important role in the transmission of the virus and act as a reservoir. The aim of this study was to determine the HPV-genotypes and their prevalence in a group of men attending a Sexually Transmitted Infection service. PATIENTS AND SAMPLES: Between July 2002 and June 2011, 1392 balanopreputial, 435 urethral, 123 anal, and 67 condyloma lesions from 1551 men with a mean age of 35.8±11.3 years old (range: 17-87) were collected for HPV-DNA testing.
Methods: A fragment of the L1-gene and a fragment of the E6/E7-genes were amplified by PCR. Positive samples were typed by hybridization.
Results: The HPV genome was detected in 36.9% (486/1318) balanopreputial and in 24.9% (101/405) urethral (p<0.0001) swabs from 38.1% (538) of 1469 men. Co-infections were present in 5.4% (80/1469) of cases. HPV was found in 43.9% (373/850) of men younger than 35 vs. 31.7% (187/589) of men aged >35. HPV was found in 59.4% (104) of 165 men with lesions (macroscopic or positive peniscopy), and in 22.8% (61/267) without clinical alterations. HPV was also detected in 71.4% (40/56) men with condylomata and in 58.7% (64/109) of men with positive peniscopy.
Conclusions: HPV prevalence in men was high and decreased with age. HPV was found more frequently in balanopreputial than in urethral swabs. There was a low rate of co-infections. Low-risk HPV vaccine genotypes were the most recurrent especially in younger. Although HPV has been associated with clinical alterations, it was also found in men without any clinical presentation. Inclusion of men in the national HPV vaccination program may reduce their burden of HPV-related disease and reduce transmission of the virus to non-vaccinated women.
References: Mod Pathol. 2010 Jan;23(1):144-50. (PMID: 19838162)
Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2036-43. (PMID: 18708396)
J Med Virol. 2010 Apr;82(4):597-604. (PMID: 20166173)
Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1077-83. (PMID: 19318438)
Prev Med. 2011 Oct;53 Suppl 1:S12-21. (PMID: 21962466)
Int J Cancer. 2007 Aug 1;121(3):621-32. (PMID: 17405118)
Lancet Oncol. 2012 Jan;13(1):10-2. (PMID: 22075169)
J Infect Dis. 2003 Apr 1;187(7):1064-70. (PMID: 12660920)
J Infect Dis. 2004 Feb 15;189(4):677-85. (PMID: 14767822)
MMWR Morb Mortal Wkly Rep. 2010 May 28;59(20):630-2. (PMID: 20508594)
J Pediatr. 1998 Feb;132(2):277-84. (PMID: 9506641)
Sex Health. 2010 Sep;7(3):244-52. (PMID: 20719211)
Lancet Oncol. 2012 May;13(5):487-500. (PMID: 22445259)
J Virol Methods. 2008 Apr;149(1):136-43. (PMID: 18279976)
J Med Virol. 2010 Aug;82(8):1424-30. (PMID: 20572068)
J Clin Pathol. 2009 Oct;62(10):870-8. (PMID: 19706632)
Lancet Infect Dis. 2006 Jan;6(1):21-31. (PMID: 16377531)
Fertil Steril. 2010 Oct;94(5):1723-7. (PMID: 20056213)
J Clin Pathol. 2002 Apr;55(4):244-65. (PMID: 11919208)
Vaccine. 2008 Aug 19;26 Suppl 10:K17-28. (PMID: 18847554)
J Infect Dis. 2008 Sep 15;198(6):827-35. (PMID: 18657037)
Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1107-14. (PMID: 17548671)
J Med Virol. 2008 Jul;80(7):1275-81. (PMID: 18461608)
Indian J Med Res. 2009 Sep;130(3):222-33. (PMID: 19901431)
J Infect Dis. 2002 Nov 15;186(10):1396-402. (PMID: 12404154)
PLoS One. 2012;7(7):e40988. (PMID: 22815888)
CMAJ. 2003 Sep 2;169(5):431-4. (PMID: 12952805)
J Infect Dis. 1997 Aug;176(2):353-61. (PMID: 9237700)
J Infect Dis. 2007 Oct 15;196(8):1146-52. (PMID: 17955432)
J Pathol. 1991 Nov;165(3):243-6. (PMID: 1662265)
Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1710-6. (PMID: 16030106)
Lancet Infect Dis. 2012 Aug;12(8):627-34. (PMID: 22445354)
Int J Epidemiol. 2010 Feb;39(1):166-81. (PMID: 20022926)
Epidemiology. 2010 Jan;21(1):31-7. (PMID: 19907332)
J Med Virol. 2009 Dec;81(12):2007-11. (PMID: 19856467)
J BUON. 2009 Jul-Sep;14(3):391-8. (PMID: 19810128)
Am J Epidemiol. 2003 Jun 1;157(11):966-72. (PMID: 12777359)
J Pathol. 1999 Sep;189(1):12-9. (PMID: 10451482)
Br J Cancer. 2003 Jan 13;88(1):63-73. (PMID: 12556961)
Int J Cancer. 2006 Oct 15;119(8):1934-9. (PMID: 16708372)
Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2389-400. (PMID: 20826836)
Int J Cancer. 2010 Jan 15;126(2):572-7. (PMID: 19626601)
Arch Otolaryngol Head Neck Surg. 1999 Jul;125(7):743-8. (PMID: 10406310)
المشرفين على المادة: 0 (Capsid Proteins)
0 (HPV L1 protein, Human papillomavirus)
0 (Oncogene Proteins, Viral)
0 (Papillomavirus E7 Proteins)
تواريخ الأحداث: Date Created: 20130202 Date Completed: 20130722 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3553085
DOI: 10.1371/journal.pone.0054375
PMID: 23372715
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0054375