دورية أكاديمية
Biochemical features of hepatic dysfunction in Nigerians with sickle cell anaemia.
| العنوان: | Biochemical features of hepatic dysfunction in Nigerians with sickle cell anaemia. |
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| المؤلفون: | Yahaya IA; Department of Chemical Pathology, Bayero University, Kano and Aminu Kano Teaching Hospital, Kano. Nigeria. |
| المصدر: | The Nigerian postgraduate medical journal [Niger Postgrad Med J] 2012 Dec; Vol. 19 (4), pp. 204-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: published by Wolters Kluwer-Medknow for the Nigerian Postgraduate Medical College of Nigeria Country of Publication: Nigeria NLM ID: 9613595 Publication Model: Print Cited Medium: Print ISSN: 1117-1936 (Print) NLM ISO Abbreviation: Niger Postgrad Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2015- > : Mumbai : published by Wolters Kluwer-Medknow for the Nigerian Postgraduate Medical College of Nigeria Original Publication: Ebute Metta, Lagos, Nigeria : National Postgraduate Medical College of Nigeria, [1994- |
| مواضيع طبية MeSH: | Liver*/metabolism , Liver*/pathology , Liver Diseases*/etiology , Liver Diseases*/metabolism , Liver Diseases*/pathology, Anemia, Sickle Cell/*complications , Antisickling Agents/*adverse effects, Adolescent ; Adult ; Alkaline Phosphatase/blood ; Anemia, Sickle Cell/drug therapy ; Anemia, Sickle Cell/epidemiology ; Bilirubin/blood ; Female ; Humans ; Liver Function Tests/methods ; Male ; Nigeria/epidemiology ; Serum Albumin ; Transaminases/blood |
| مستخلص: | Aims and Objectives: This study seeks to document the biochemical manifestations of liver dysfunction in Nigerians with sickle cell anaemia with the aim of alerting physicians on the need to consider these changes in the overall management of the disease condition. Patients and Methods: Serum total proteins, albumin, bilirubin, alkaline phosphatase (ALP), alanine aminotransferase(ALT) and aspartate aminotransferase(AST) levels were estimated in 150 patients with sickle cell anaemia (HbSS) and 100 control (HbAA) subjects. Results: The serum total proteins and albumin levels were found to fall within the reference intervals in both the HbSSpatients and the controls. However, the mean bilirubin (total and conjugated) levels and the activities of alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase were significantly higher (P<0.05) in the HbSSpatients than the control subjects. Conclusion: This study demonstrated elevated levels of serum bilirubin, ALP, ALT and AST in patients with sickle cell anaemia. |
| المشرفين على المادة: | 0 (Antisickling Agents) 0 (Serum Albumin) EC 2.6.1.- (Transaminases) EC 3.1.3.1 (Alkaline Phosphatase) RFM9X3LJ49 (Bilirubin) |
| تواريخ الأحداث: | Date Created: 20130207 Date Completed: 20130701 Latest Revision: 20220408 |
| رمز التحديث: | 20240628 |
| PMID: | 23385674 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1117-1936 |
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