دورية أكاديمية
أعرض في EDS

Is there association between uric acid and inflammation in hemodialysis patients?

التفاصيل البيبلوغرافية
العنوان: Is there association between uric acid and inflammation in hemodialysis patients?
المؤلفون: Lobo JC; Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Stockler-Pinto MB, da Nóbrega AC, Carraro-Eduardo JC, Mafra D
المصدر: Renal failure [Ren Fail] 2013; Vol. 35 (3), pp. 361-6. Date of Electronic Publication: 2013 Feb 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: New York, N.Y. : M. Dekker, c1987-
مواضيع طبية MeSH: Inflammation/*blood , Kidney Failure, Chronic/*blood , Uric Acid/*blood, Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Regression Analysis ; Renal Dialysis
مستخلص: Background: Elevated serum uric acid has been associated with a variety of cardiovascular disease and with inflammation, but these have been little explored in chronic kidney disease (CKD). Elevated uric acid levels are common in CKD patients and could be involved in inflammatory milieu; our aim was to analyze the association between uric acid and inflammatory markers in hemodialysis (HD) patients.
Design: This was a cross-sectional study.
Setting: This study was conducted from private clinic, Rio de Janeiro, Brazil.
Patients: This study included 50 HD patients and 21 healthy subjects.
Methods and Procedures: This study included 50 HD patients [62% men, 54.3 ± 12.6 years, 57.5 ± 50.1 months on dialysis, and body mass index (BMI), 24.4 ± 4.1 kg/m2] and 21 healthy individuals (45% men, 50.7 ± 15.7 years and BMI, 25.5 ± 4 kg/m2). Uric acid was measured using uricase-PAP method; inflammatory [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP)] and atherosclerosis markers [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1)] were measured by a multiplexed assay.
Results: PATIENTS presented high levels of TNF-α, IL-6, CRP, VCAM-1, ICAM-1 (5.5 ± 2.1 pg/mL, 4.1 ± 1.6 pg/mL, 0.32 ± 0.30 mg/mL, 48.5 ± 8.5 ng/mL, 20.5 ± 15.9 ng/mL, respectively), compared with healthy individuals (2.4 ± 1.1 pg/mL, 2.7 ± 0.4 pg/mL, 0.11 ± 0.12 mg/mL, 23.8 ± 5.5 ng/mL, 7.2 ± 1.2 ng/mL, respectively) ( p < 0.04). Uric acid levels were also higher in HD patients (5.4 ± 1.3 mg/dL) than in healthy individuals (3.9 ± 0.9 mg/dL) ( p < 0.02). There was a positive correlation between uric acid and inflammatory markers, IL-6 (r = 0.30, p = 0.01), CRP (r = 0.37, p = 0.003), TNF-α (r = 0.40, p = 0.001), ICAM-1 (r = 0.53, p = 0.0001), and VCAM-1 (r = 0.45, p = 0.0001).
Conclusion: These original data suggest that uric acid may have a role in inflammation and atherosclerosis in HD patients. However, further prospective studies involving intervention trials should be conducted in order to search for actual causality relationship between these markers.
المشرفين على المادة: 268B43MJ25 (Uric Acid)
تواريخ الأحداث: Date Created: 20130212 Date Completed: 20131216 Latest Revision: 20220318
رمز التحديث: 20231215
DOI: 10.3109/0886022X.2013.764274
PMID: 23394103
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-6049
DOI:10.3109/0886022X.2013.764274