دورية أكاديمية
Acute perforated peptic ulcer: on clinical experience in an urban tertiary hospital in south east Nigeria.
| العنوان: | Acute perforated peptic ulcer: on clinical experience in an urban tertiary hospital in south east Nigeria. |
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| المؤلفون: | Ugochukwu AI; Department of Surgery, Enugu State University Teaching Hospital, Enugu, Nigeria., Amu OC, Nzegwu MA, Dilibe UC |
| المصدر: | International journal of surgery (London, England) [Int J Surg] 2013; Vol. 11 (3), pp. 223-7. Date of Electronic Publication: 2013 Feb 09. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101228232 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-9159 (Electronic) Linking ISSN: 17439159 NLM ISO Abbreviation: Int J Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [Philadelphia] : Wolters Kluwer Health, Inc. Original Publication: London : Surgical Associates Ltd., c2004- |
| مواضيع طبية MeSH: | Peptic Ulcer Perforation/*diagnosis , Peptic Ulcer Perforation/*surgery, Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Nigeria |
| مستخلص: | Background: Acute perforated peptic ulcer is a leading cause of generalized peritonitis and its management has continued to be a challenging task in our environment. Objective: There is a paucity of published reports on acute perforated peptic ulcers in our environment. This study was conducted to evaluate the different pattern of risk factors clinical presentations, management and clinical outcome of patients with acute perforated peptic ulcer in our setting and to highlight the factors that continue to account for the high mortality and morbidity as seen here. Method: A retrospective study where data of seventy-six (76) patients managed for generalized peritonitis due to acute peptic ulcer perforation over a five year period (January 2006-December 2010) were retrieved from medical records of Enugu State University of Science and Technology Hospital (ESUTH). The patients' biodata, clinical and operative findings and treatment outcome were extracted and analysed, after institutional ethical approval was secured. All other cases of generalized peritonitis not traceable to acute peptic ulcer perforation were excluded from the study. Results: There were76 patients; 58 males and 18 females (M:F = 3.2:1) Their ages ranged from 20 to 80years with a mean of 39.5yr and SD ± 13.10years. Majority of the patients 49(64.4%) were 40years of age and below and only 24 (31.6%) had a previous history suggestive of chronic peptic ulcer disease. Twenty five (32.9%) patients presented within 24 h of onset of symptoms of perforation with a mortality of 8.0%. Slightly more than half of our patients 39(51.3%) presented between 24 and 48 h with mortality of 17.9%. Twelve patients (15.8%) presented between 48 and 72 h and the mortality in this group was 58.3%. The latter two groups accounted for most of the mortality in our series. All perforations were anterior perforations within the first 2.5 cm of the duodenum and all had simple closure with pedicled omental patch and peritoneal toilet with copious volumes of warm normal saline. Postoperatively all received Helicobacter pylori eradication therapy and proton pump inhibitors for at least two months. Conclusion: Patient groups who presented early had low mortality rates, but patient groups who presented late had higher mortality rates. Overall mortality was 21%. (Copyright © 2013. Published by Elsevier Ltd.) |
| تواريخ الأحداث: | Date Created: 20130214 Date Completed: 20131118 Latest Revision: 20130325 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ijsu.2013.01.015 |
| PMID: | 23403213 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1743-9159 |
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| DOI: | 10.1016/j.ijsu.2013.01.015 |