دورية أكاديمية
أعرض في EDS

Effects of high-protein versus high-carbohydrate diets on markers of β-cell function, oxidative stress, lipid peroxidation, proinflammatory cytokines, and adipokines in obese, premenopausal women without diabetes: a randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: Effects of high-protein versus high-carbohydrate diets on markers of β-cell function, oxidative stress, lipid peroxidation, proinflammatory cytokines, and adipokines in obese, premenopausal women without diabetes: a randomized controlled trial.
المؤلفون: Kitabchi AE; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA. akitabch@uthsc.edu, McDaniel KA, Wan JY, Tylavsky FA, Jacovino CA, Sands CW, Nyenwe EA, Stentz FB
المصدر: Diabetes care [Diabetes Care] 2013 Jul; Vol. 36 (7), pp. 1919-25. Date of Electronic Publication: 2013 Feb 12.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
أسماء مطبوعة: Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn.
مواضيع طبية MeSH: Dietary Carbohydrates* , Dietary Proteins*, Adipokines/*metabolism , Cytokines/*metabolism , Insulin-Secreting Cells/*metabolism , Lipid Peroxidation/*physiology , Obesity/*metabolism , Oxidative Stress/*physiology, Adult ; Female ; Humans ; Middle Aged ; Premenopause ; Risk Factors ; Weight Loss ; Young Adult
مستخلص: Objective: To study the effects of high-protein versus high-carbohydrate diets on various metabolic end points (glucoregulation, oxidative stress [dichlorofluorescein], lipid peroxidation [malondialdehyde], proinflammatory cytokines [tumor necrosis factor-α and interleukin-6], adipokines, and resting energy expenditure [REE]) with high protein-low carbohydrate (HP) and high carbohydrate-low protein (HC) diets at baseline and after 6 months of dietary intervention.
Research Design and Methods: We recruited obese, premenopausal women aged 20-50 years with no diabetes or prediabetes who were randomized to HC (55% carbohydrates, 30% fat, and 15% protein) or HP (40% carbohydrates, 30% fat, and 30% protein) diets for 6 months. The diets were provided in prepackaged food, which provided 500 kcal restrictions per day. The above metabolic end points were measured with HP and HC diet at baseline and after 6 months of dietary intervention.
Results: After 6 months of the HP versus HC diet (12 in each group), the following changes were significantly different by Wilcoxon rank sum test for the following parameters: dichlorofluorescein (-0.8 vs. -0.3 µmol/L, P < 0.0001), malondialdehyde (-0.4 vs. -0.2 μmol/L, P = 0.0004), C-reactive protein (-2.1 vs. -0.8 mg/L, P = 0.0003), E-selectin (-8.6 vs. -3.7 ng/mL, P = 0.0007), adiponectin (1,284 vs. 504 ng/mL, P = 0.0011), tumor necrosis factor-α (-1.8 vs. -0.9 pg/mL, P < 0.0001), IL-6 (-1.3 vs. -0.4 pg/mL, P < 0.0001), free fatty acid (-0.12 vs. 0.16 mmol/L, P = 0.0002), REE (259 vs. 26 kcal, P < 0.0001), insulin sensitivity (4 vs. 0.9, P < 0.0001), and β-cell function (7.4 vs. 2.1, P < 0.0001).
Conclusions: To our knowledge, this is the first report on the significant advantages of a 6-month hypocaloric HP diet versus hypocaloric HC diet on markers of β-cell function, oxidative stress, lipid peroxidation, proinflammatory cytokines, and adipokines in normal, obese females without diabetes.
References: J Am Diet Assoc. 1991 Dec;91(12):1538-42. (PMID: 1960346)
Biochem Biophys Res Commun. 2005 Sep 23;335(2):491-5. (PMID: 16084832)
JAMA. 2002 May 8;287(18):2414-23. (PMID: 11988062)
J Nutr. 2004 Apr;134(4):968S-73S. (PMID: 15051856)
N Engl J Med. 2001 Sep 13;345(11):790-7. (PMID: 11556298)
Ann Intern Med. 2005 Mar 15;142(6):403-11. (PMID: 15767618)
Am J Clin Nutr. 2001 Jul;74(1):57-63. (PMID: 11451718)
Biochem Biophys Res Commun. 2006 Aug 4;346(3):721-6. (PMID: 16782068)
J Am Diet Assoc. 2002 Nov;102(11):1621-30. (PMID: 12449285)
N Engl J Med. 2010 Nov 25;363(22):2102-13. (PMID: 21105792)
Diabetes Care. 1999 Sep;22(9):1462-70. (PMID: 10480510)
Nutr Rev. 2002 Jul;60(7 Pt 1):189-200. (PMID: 12144197)
Nutr Metab (Lond). 2008 Nov 07;5:30. (PMID: 18990242)
Metabolism. 2011 Jan;60(1):1-23. (PMID: 21134520)
Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825)
N Engl J Med. 2011 Mar 24;364(12):1104-15. (PMID: 21428766)
J Nutr. 2006 Jul;136(7):1849-54. (PMID: 16772448)
Diabetes. 2003 Dec;52(12):2882-7. (PMID: 14633847)
Diabetes. 2004 Aug;53(8):2079-86. (PMID: 15277389)
N Engl J Med. 2003 May 22;348(21):2074-81. (PMID: 12761364)
JAMA. 2002 Oct 9;288(14):1723-7. (PMID: 12365955)
Diabetes Care. 2011 Jan;34 Suppl 1:S4-10. (PMID: 21193627)
J Clin Endocrinol Metab. 2000 Aug;85(8):2970-3. (PMID: 10946914)
JAMA. 1994 Dec 28;272(24):1942-8. (PMID: 7990248)
J Am Diet Assoc. 2002 Oct;102(10):1445-51. (PMID: 12396164)
Am J Clin Nutr. 2006 Feb;83(2):260-74. (PMID: 16469983)
JAMA. 2012 Jun 27;307(24):2641-2. (PMID: 22735436)
JAMA. 2004 Nov 24;292(20):2482-90. (PMID: 15562127)
Nutr Metab (Lond). 2011 Mar 04;8(1):13. (PMID: 21375752)
Metabolism. 1988 Mar;37(3):287-301. (PMID: 3278194)
JAMA. 2012 Jan 4;307(1):86-7. (PMID: 22215169)
J Clin Endocrinol Metab. 2001 Jan;86(1):355-62. (PMID: 11232024)
JAMA. 2012 Jan 4;307(1):47-55. (PMID: 22215165)
Diabetes Care. 1984 Sep-Oct;7(5):465-70. (PMID: 6389060)
Biochem Biophys Res Commun. 2004 Mar 5;315(2):404-7. (PMID: 14766222)
Am J Clin Nutr. 1990 Jul;52(1):72-80. (PMID: 2193503)
Metabolism. 1994 Dec;43(12):1481-7. (PMID: 7990700)
J Nutr. 2003 Feb;133(2):405-10. (PMID: 12566475)
J Am Diet Assoc. 1990 Apr;90(4):534-40. (PMID: 2319073)
معلومات مُعتمدة: T35 DK007405 United States DK NIDDK NIH HHS; C5T35DK007405-28 United States DK NIDDK NIH HHS
المشرفين على المادة: 0 (Adipokines)
0 (Cytokines)
0 (Dietary Carbohydrates)
0 (Dietary Proteins)
تواريخ الأحداث: Date Created: 20130214 Date Completed: 20140203 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3687312
DOI: 10.2337/dc12-1912
PMID: 23404297
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-5548
DOI:10.2337/dc12-1912