دورية أكاديمية
Longitudinal study of hormonal and physical development in young twins.
| العنوان: | Longitudinal study of hormonal and physical development in young twins. |
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| المؤلفون: | Koenis MM; Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. m.m.g.koenis@umcutrecht.nl, Brouwer RM, van Baal GC, van Soelen IL, Peper JS, van Leeuwen M, Delemarre-van de Waal HA, Boomsma DI, Hulshoff Pol HE |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2013 Mar; Vol. 98 (3), pp. E518-27. Date of Electronic Publication: 2013 Feb 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مواضيع طبية MeSH: | Child Development/*physiology , Endocrine System/*growth & development , Gonadal Steroid Hormones/*blood , Gonadal Steroid Hormones/*genetics, Child ; Endocrine System/metabolism ; Environment ; Estradiol/blood ; Estradiol/genetics ; Female ; Follicle Stimulating Hormone, Human/blood ; Follicle Stimulating Hormone, Human/genetics ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Luteinizing Hormone/blood ; Luteinizing Hormone/genetics ; Male ; Puberty/genetics ; Puberty/physiology ; Sexual Development/genetics ; Sexual Development/physiology ; Testosterone/blood ; Testosterone/genetics |
| مستخلص: | Context and Objective: Information on the correlation of normative reproductive hormone levels with physical development (Tanner stages) during puberty and on the influences of genes and environment on variation in these hormones and Tanner stages is limited. Design, Setting, and Participants: One hundred twelve healthy 9-year-old twin pairs (n = 224) took part in a longitudinal study, of which 89 pairs participated again at age 12 years (n = 178). Main Outcome Measures: Morning urinary LH, FSH, estradiol, and salivary testosterone levels, determined by competitive immunoassays, were measured. Tanner stages were determined through physical examination. Results: Over the 3-year interval, all hormone levels showed a 2- to 9-fold increase. LH and FSH at age 9 years predicted sex-specific Tanner stages at age 12 years in both boys and girls. Most of the associations between hormone levels at age 9 years and physical development at 12 years were explained by genetic influences. FSH in 9-year-old boys correlated with all hormone levels and Tanner stages at age 12 years. Moderate to high heritability estimates were found for hormone levels at both ages and in both sexes. In girls a shift from environmental (age 9 years) to genetic influences (age 12 years) was found for estradiol and pubic hair development, and for breast development a shift in the opposite direction was seen. Conclusions: During development LH and FSH (and testosterone in boys) levels predict secondary sexual characteristics in boys and girls 3 years later. These correlations are largely due to genes that are involved in both early pubertal hormone levels and subsequent physical development. |
| المشرفين على المادة: | 0 (Follicle Stimulating Hormone, Human) 0 (Gonadal Steroid Hormones) 3XMK78S47O (Testosterone) 4TI98Z838E (Estradiol) 9002-67-9 (Luteinizing Hormone) |
| تواريخ الأحداث: | Date Created: 20130223 Date Completed: 20130430 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1210/jc.2012-3361 |
| PMID: | 23430788 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7197 |
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| DOI: | 10.1210/jc.2012-3361 |