A Study of Association of Ankle Brachial Index (ABI) and the Highly Sensitive C - Reactive Protein (hsCRP) in Type 2 Diabetic Patients and in Normal Subjects.

التفاصيل البيبلوغرافية
العنوان:	A Study of Association of Ankle Brachial Index (ABI) and the Highly Sensitive C - Reactive Protein (hsCRP) in Type 2 Diabetic Patients and in Normal Subjects.
المؤلفون:	K O T; Assistant Professor, Department of Physiology, SSMC , Tumkur, India ., M S R, G D, S P C, Kumar K M P
المصدر:	Journal of clinical and diagnostic research : JCDR [J Clin Diagn Res] 2013 Jan; Vol. 7 (1), pp. 46-50. Date of Electronic Publication: 2012 Oct 14.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Published by Dr. Hemant Jain for Premchand Shantidevi Research Foundation, India Country of Publication: India NLM ID: 101488993 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2249-782X (Print) Linking ISSN: 0973709X NLM ISO Abbreviation: J Clin Diagn Res Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: India : Published by Dr. Hemant Jain for Premchand Shantidevi Research Foundation, India
مستخلص:	Background: The Ankle-Brachial Index (ABI) objectively assesses the lower extremity arterial perfusion. A low ABI suggests atherosclerosis and Peripheral Arterial Disease (PAD). PAD is more common in individuals with type2 Diabetes mellitus (Type2 DM). Inflammatory markers are found to be associated with Type2 DM. But the association of the inflammatory markers with the atherosclerotic burden remains poorly defined. Aims: To compare the ABI and the hsCRP in the Type 2 DM patients with those in the normal subjects and to study the association of serum hsCRP with ABI in the Type 2 DM patients and in normal subjects. Methods: The subjects were 40 Type2 DM and 40 age, sex and BMI matched normal subjects who were aged between 45-60 yrs. The subjects were assigned to two different groups, Group1- the Type2 DM patients and Group2- the healthy controls. The serum hsCRP levels were determined by the turbidimetry method (BIOSYSTEMS) and the ABI values were determined by using the traditional continuous wave (CW) Doppler of NICOLET VERSALAB. Statistical Analysis: The data was analyzed by using the Student's t test (two tailed; independent) to find the significance of the study parameters between the two groups. Pearson's Correlation was used to find the correlation of serum hsCRP with the ABI in the two groups. Results: The ABI showed a significantly low value (P=0.035) and the serum hsCRP showed a trend towards a significant increase (p = 0.069+) in the type2diabetics as compared to those in the normals. There was a significant negative correlation between ABI and hsCRP in the Type 2 DM patients (r=-0.560, p<0.001*). However, such correlation was not observed in the normal subjects. Conclusion: As serum hsCRP is associated with ABI in the type2 DM patients, inflammation may play a role in the pathogenesis of atherosclerosis.
References:	Am Fam Physician. 1998 Mar 15;57(6):1325-32, 1337-8. (PMID: 9531915) Circulation. 2000 Aug 29;102(9):994-9. (PMID: 10961963) Circulation. 2005 Aug 16;112(7):976-83. (PMID: 16087797) Rev Clin Esp. 2006 May;206(5):225-9. (PMID: 16750105) Diabetes Care. 2004 Jun;27(6):1381-6. (PMID: 15161792) BMJ. 2001 Jan 6;322(7277):4-5. (PMID: 11141130) Diabetes Care. 2000 Sep;23(9):1295-300. (PMID: 10977021) Eur Heart J. 2002 Jun;23(11):831-4. (PMID: 12042000) Med Clin (Barc). 2005 Mar 12;124(9):336-7. (PMID: 15760600) Vasc Med. 2004 May;9(3):171-6. (PMID: 15675180) Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):538-45. (PMID: 10073955) Proc Soc Exp Biol Med. 1971 Feb;136(2):612-4. (PMID: 4395924) Cardiol Clin. 2002 Nov;20(4):491-500, v. (PMID: 12472037) Age Ageing. 2006 Jan;35(1):60-5. (PMID: 16364935) Ann Med. 2000 May;32(4):274-8. (PMID: 10852144) N Engl J Med. 2000 Mar 23;342(12):836-43. (PMID: 10733371) BMJ. 1996 Dec 7;313(7070):1440-4. (PMID: 8973232)
فهرسة مساهمة:	Keywords: Ankle-brachial Index (ABI); Atherosclerosis; Highly sensitive C - reactive protein (hsCRP); Peripheral arterial disease; Type 2 Diabetes Mellitus
تواريخ الأحداث:	Date Created: 20130302 Date Completed: 20130501 Latest Revision: 20220409
رمز التحديث:	20240628
مُعرف محوري في PubMed:	PMC3576748
DOI:	10.7860/JCDR/2012/4854.2667
PMID:	23450165
قاعدة البيانات:	MEDLINE

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تدمد:	2249-782X
DOI:	10.7860/JCDR/2012/4854.2667