دورية أكاديمية
Developmental changes in testicular interstitial cell populations, LH receptors and in the response to hCG in the rat.
| العنوان: | Developmental changes in testicular interstitial cell populations, LH receptors and in the response to hCG in the rat. |
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| المؤلفون: | Leon MD; Centro de Investigaciones Endocrinologicas, Hospital de Ninos R. Gutierrez, Buenos Aires, Argentina., Calvo JC, Charreau EH, Chemes HE |
| المصدر: | International journal of andrology [Int J Androl] 1990 Apr; Vol. 13 (2), pp. 110-22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Country of Publication: England NLM ID: 8000141 Publication Model: Print Cited Medium: Print ISSN: 0105-6263 (Print) Linking ISSN: 01056263 NLM ISO Abbreviation: Int J Androl Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Copenhagen, Scriptor. |
| مواضيع طبية MeSH: | Chorionic Gonadotropin/*pharmacology , Leydig Cells/*cytology , Receptors, LH/*drug effects, Aging/metabolism ; Androgens/biosynthesis ; Animals ; Cell Division/drug effects ; Leydig Cells/drug effects ; Male ; Rats ; Receptors, LH/metabolism ; Seminiferous Tubules/cytology ; Seminiferous Tubules/drug effects ; Testosterone/blood |
| مستخلص: | High doses of hCG were administered to immature rats of different ages and the animals killed 48 h later. Serum testosterone increased 2 to 4-fold over control values 48 h after hCG. In-vitro androgen production showed different patterns according to age. Animals younger than 35 days, when treated with hCG, retained the ability to respond to in-vitro gonadotrophic stimulation. This ability was lost in testes from rats aged 45 days. The number of free LH-receptors 48 h after hCG diminished with increasing age to become non-detectable at 35 and 45 days. In control animals the proportion of differentiated Leydig cells in relation to their mesenchymal precursors increased progressively with age to reach highest values at 45 days. hCG administration induced a shift of the cellular composition of the interstitium toward the more mature cell types. hCG has a predominantly trophic action on mesenchymal precursors in young rats, promoting their differentiation. These effects are minimal in the differentiated Leydig cells in older animals. It is proposed that the observed biochemical responses are the result of the balance between the increase in LH receptors and steroidogenic enzymes in the developing new generation of young Leydig cells and the down-regulation of receptors and enzymatic lesions in fully differentiated Leydig cells. |
| المشرفين على المادة: | 0 (Androgens) 0 (Chorionic Gonadotropin) 0 (Receptors, LH) 3XMK78S47O (Testosterone) |
| تواريخ الأحداث: | Date Created: 19900401 Date Completed: 19900629 Latest Revision: 20190918 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1365-2605.1990.tb00968.x |
| PMID: | 2345036 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0105-6263 |
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| DOI: | 10.1111/j.1365-2605.1990.tb00968.x |