دورية أكاديمية
Cardiac troponin assay classification by both clinical and analytical performance characteristics: a study on outcome prediction.
| العنوان: | Cardiac troponin assay classification by both clinical and analytical performance characteristics: a study on outcome prediction. |
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| المؤلفون: | Venge P; Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden. per.venge@medsci.uu.se, Lindahl B |
| المصدر: | Clinical chemistry [Clin Chem] 2013 Jun; Vol. 59 (6), pp. 976-81. Date of Electronic Publication: 2013 Mar 12. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9421549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-8561 (Electronic) Linking ISSN: 00099147 NLM ISO Abbreviation: Clin Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Oxford : Oxford University Press Original Publication: Baltimore, Md. : P.B. Hoeber, [c1955- |
| مواضيع طبية MeSH: | Clinical Chemistry Tests/*methods , Myocardial Infarction/*blood , Troponin/*blood, Aged ; Clinical Chemistry Tests/standards ; Female ; Humans ; Male ; Outcome Assessment, Health Care ; Prognosis ; Reference Values ; Risk Factors |
| مستخلص: | Background: Cardiac troponin assays have been classified according to whether they measure the 99th percentile concentration of a healthy reference population with imprecision (expressed as CV) of ≤10%, between 10% and 20%, or >20%. Assays in these categories have been deemed "guideline acceptable," "clinically usable," or "not acceptable," respectively. We compared four widely used "clinically usable" cardiac troponin I (cTnI) assays with an assay designated "not acceptable" for accuracy in predicting the clinical outcome of death. Methods: Blood was collected from 259 men and 249 women, mean (SD) age 68.8 (17.8) and 70.2 (17.8) years, respectively, admitted to the emergency department for suspected myocardial infarction. We measured cTnI by the Access, Architect, i-Stat, Stratus CS, and VIDAS assays. Deaths in this population were recorded over a 31-month period. Results: We found VIDAS cTnI assay measurement CVs of 10% and 20% at concentrations of 0.04 and 0.02 μg/L, respectively. Comparing at the 10% CV cutoff concentration, VIDAS cTnI was less sensitive than the Access and Architect assays (P < 0.001) but more sensitive than i-Stat (P < 0.001) and Stratus CS (P < 0.001) in identifying patients with poor outcomes. At the 20% CV cutoff, the VIDAS assay was equivalent to the other assays in identifying patients with poor outcomes. Conclusions: For outcome prediction, the VIDAS cTnI assay was clinically equivalent or superior to other cTnI assays judged to be acceptable from a pure analytical standpoint. Thus, comparison of cardiac troponin assays should consider not only analytical performance, but also clinical performance characteristics. (© 2013 American Association for Clinical Chemistry.) |
| المشرفين على المادة: | 0 (Troponin) |
| تواريخ الأحداث: | Date Created: 20130314 Date Completed: 20130805 Latest Revision: 20191210 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1373/clinchem.2012.194928 |
| PMID: | 23481696 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1530-8561 |
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| DOI: | 10.1373/clinchem.2012.194928 |