دورية أكاديمية
أعرض في EDS

CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice.

التفاصيل البيبلوغرافية
العنوان: CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice.
المؤلفون: Meixlsperger S; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Leung CS, Rämer PC, Pack M, Vanoaica LD, Breton G, Pascolo S, Salazar AM, Dzionek A, Schmitz J, Steinman RM, Münz C
المصدر: Blood [Blood] 2013 Jun 20; Vol. 121 (25), pp. 5034-44. Date of Electronic Publication: 2013 Mar 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [New York] : Elsevier
Original Publication: New York, Grune & Stratton [etc.]
مواضيع طبية MeSH: Antigens, CD/*immunology , Dendritic Cells/*immunology , Interferon-alpha/*biosynthesis , Lectins, C-Type/*immunology , Lymphocyte Activation/*immunology , RNA, Double-Stranded/*immunology , Receptors, Cell Surface/*immunology, Animals ; Antigen Presentation/immunology ; CD8-Positive T-Lymphocytes/immunology ; Dendritic Cells/cytology ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Humans ; Interferon-alpha/immunology ; Mice ; Minor Histocompatibility Antigens
مستخلص: Functional differences between human dendritic cell (DC) subsets and the potential benefits of targeting them with vaccines remain poorly defined. Here we describe that mice with reconstituted human immune system components (huNSG mice) develop all human conventional and plasmacytoid DC compartments in lymphoid organs. Testing different Toll-like receptor agonists for DC maturation in vivo, we found that IL-12p70 and interferon (IFN)-α production correlated with the maturation of CD141+ (BDCA3+) conventional DCs in huNSG mice. Furthermore, depletion of CD141+ DCs before stimulation significantly reduced IFN-α levels in vivo. This DC subset produced similar total amounts but different subtypes of IFN-α in response to synthetic double-stranded RNA compared with plasmacytoid DCs in response to a single-stranded RNA equivalent. Moreover, synthetic double-stranded RNA as adjuvant and antigen targeting to the endocytic receptor DEC-205, a combination that focuses antigen presentation for T-cell priming on CD141+ DCs, stimulated antigen-specific human CD4+ T-cell responses. Thus, the human CD141+ DC subset is a prominent source of IFN-α and interleukin-12 production and should be further evaluated for vaccine development.
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معلومات مُعتمدة: 11-0516 United Kingdom AICR_ Worldwide Cancer Research; R01 CA108609 United States CA NCI NIH HHS; R01CA108609 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Antigens, CD)
0 (DEC-205 receptor)
0 (Interferon-alpha)
0 (Lectins, C-Type)
0 (Minor Histocompatibility Antigens)
0 (RNA, Double-Stranded)
0 (Receptors, Cell Surface)
تواريخ الأحداث: Date Created: 20130314 Date Completed: 20130821 Latest Revision: 20220129
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3689250
DOI: 10.1182/blood-2012-12-473413
PMID: 23482932
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-0020
DOI:10.1182/blood-2012-12-473413