التفاصيل البيبلوغرافية
| العنوان: |
Prognostic markers of astrocytoma: how to predict the unpredictable? |
| المؤلفون: |
Khwaja FW; Shaukat Khanum Memorial Cancer Hospital and Research Center, Basic Science Lab, Abdul Hafeez Research Wing, 77A, Block R/8, Lahore, 54000, Pakistan +92 042 5180727 ext. 2523 ; +92 042 5945207 ; fkhwaja@skm.org.pk. |
| المصدر: |
Expert opinion on medical diagnostics [Expert Opin Med Diagn] 2007 Dec; Vol. 1 (4), pp. 463-79. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Informa Healthcare Country of Publication: England NLM ID: 101392201 Publication Model: Print Cited Medium: Print ISSN: 1753-0059 (Print) Linking ISSN: 17530059 NLM ISO Abbreviation: Expert Opin Med Diagn Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: |
Original Publication: London : Informa Healthcare |
| مستخلص: |
Astrocytomas are the most frequent tumors originating in the human nervous system. They carry a dismal prognosis as high-grade astroctyoma patients (World Health Organization [WHO] grade III and IV) rarely live beyond 5 years. At present, these tumors are mainly diagnosed through the difficult task of histologic examination of tissue obtained through stereotactic biopsy or tumor resection. In addition to determining the malignancy grade through histologic studies, the only other prognostic factors used in clinical setting are patient age and performance status. To overcome current limitations, research is underway to develop molecular approaches for glioma classification. These include identification, characterization and expansion of clinical (patient characteristics and imaging variables), histologic (WHO classification criteria) and molecular (genetic and proteomic) factors with prognostic potential. In this review the established classification characteristics, along with recent advances that may lead to the addition of new parameters and thus improve patient management and survival, are discussed. |
| تواريخ الأحداث: |
Date Created: 20130319 Date Completed: 20130319 Latest Revision: 20130318 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1517/17530059.1.4.463 |
| PMID: |
23496354 |
| قاعدة البيانات: |
MEDLINE |
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