دورية أكاديمية
The oxidative response of mouse hearts is modulated by genetic background.
| العنوان: | The oxidative response of mouse hearts is modulated by genetic background. |
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| المؤلفون: | Santos-Silva MA; Universidade Severino Sombra, Vassouras, RJ, Brasil., Nagato AC, Trajano ET, Alves JN, Bandeira AC, Porto LC, Bezerra FS |
| المصدر: | Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2013 Feb; Vol. 100 (2), pp. 157-63. |
| نوع المنشور: | Journal Article |
| اللغة: | English; Portuguese |
| بيانات الدورية: | Publisher: Sociedad Brasileira De Cardiologia Country of Publication: Brazil NLM ID: 0421031 Publication Model: Print Cited Medium: Internet ISSN: 1678-4170 (Electronic) Linking ISSN: 0066782X NLM ISO Abbreviation: Arq Bras Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sao Paulo : Sociedad Brasileira De Cardiologia |
| مواضيع طبية MeSH: | Oxidative Stress*/genetics, Catalase/*metabolism , Glutathione/*metabolism , Myocardium/*metabolism , Peroxidase/*metabolism , Tobacco Smoke Pollution/*adverse effects, Analysis of Variance ; Animals ; Catalase/genetics ; Glutathione/genetics ; Heart ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Models, Animal ; Oxidation-Reduction ; Peroxidase/genetics ; Random Allocation ; Species Specificity ; Statistics, Nonparametric |
| مستخلص: | Background: Smoking plays an important role in cardiovascular diseases. However, the reasons why some individuals develop those diseases and others do not remain to be explained. Objective: This study aimed at assessing the redox profile of the heart of different mouse strains after exposure to cigarette smoke. Methods: Male mice of the Swiss (n = 10), C3H (n = 10), BALB/c (n = 10) and C57BL/6 (n = 10) strains were exposed to cigarette smoke (12 cigarettes/day), while their respective controls (n = 10) were exposed to ambient air for 60 days. After being euthanized, their heart was removed for biochemical analyses. Results: Although the malondialdehyde content did not increase in any of the groups, catalase activity decreased in the Swiss (p < 0.05) and BALB/c (p < 0.05) strain mice as compared with their respective control groups, while myeloperoxidase decreased in the C3H (p < 0.05) and C57BL/6 (p < 0.001) strain mice as compared with their respective control groups. The reduced glutathione content decreased in the Swiss, C3H, C57BL/6 (p < 0.05) and BALB/c (p < 0,001) strain mice as compared with their respective control groups. Regarding reduced glutathione content, an increase was observed in the Swiss strain mice (p < 0.05), while a decrease was observed in the C3H (p < 0.05) and BALB/c (p < 0.001) strain mice as compared with their respective control groups. The reduced glutathione/reduced glutathione ratio showed a reduction in the Swiss and C57BL/6 (p < 0.05) strain mice as compared with their respective control groups. Conclusions: The genetic background of mice can influence the antioxidant response after exposure to cigarette smoke and seems to be a determinant factor for redox imbalance in Swiss and C57BL/6 strain mice. Understanding antioxidant responses and genetic background of C3H and BALB/c strain mice might provide important information regarding cardiac resistance to cigarette smoke. |
| المشرفين على المادة: | 0 (Tobacco Smoke Pollution) EC 1.11.1.6 (Catalase) EC 1.11.1.7 (Peroxidase) GAN16C9B8O (Glutathione) |
| تواريخ الأحداث: | Date Created: 20130319 Date Completed: 20130820 Latest Revision: 20190606 |
| رمز التحديث: | 20221213 |
| DOI: | 10.5935/abc.20130029 |
| PMID: | 23503825 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-4170 |
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| DOI: | 10.5935/abc.20130029 |