دورية أكاديمية
Morphological modification of the cornea after standard and transepithelial corneal cross-linking as imaged by anterior segment optical coherence tomography and laser scanning in vivo confocal microscopy.
| العنوان: | Morphological modification of the cornea after standard and transepithelial corneal cross-linking as imaged by anterior segment optical coherence tomography and laser scanning in vivo confocal microscopy. |
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| المؤلفون: | Mastropasqua L; Department of Medicine and Ageing Sciences, Ophthalmology Clinic, University G. D'Annunzio of Chieti and Pescara, Pescara, Italy., Nubile M, Lanzini M, Calienno R, Mastropasqua R, Agnifili L, Toto L |
| المصدر: | Cornea [Cornea] 2013 Jun; Vol. 32 (6), pp. 855-61. |
| نوع المنشور: | Comparative Study; Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8216186 Publication Model: Print Cited Medium: Internet ISSN: 1536-4798 (Electronic) Linking ISSN: 02773740 NLM ISO Abbreviation: Cornea Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, N.Y. : Masson Pub. USA, c1982- |
| مواضيع طبية MeSH: | Photochemotherapy*, Corneal Edema/*diagnosis , Corneal Keratocytes/*pathology , Cross-Linking Reagents/*therapeutic use , Keratoconus/*drug therapy, Adolescent ; Adult ; Cell Count ; Collagen/metabolism ; Corneal Pachymetry ; Corneal Stroma/metabolism ; Corneal Topography ; Female ; Humans ; Keratoconus/metabolism ; Male ; Microscopy, Confocal ; Photosensitizing Agents/therapeutic use ; Prospective Studies ; Riboflavin/therapeutic use ; Tomography, Optical Coherence ; Ultraviolet Rays ; Young Adult |
| مستخلص: | Purpose: In vivo analysis of corneal modifications after traditional and transepithelial corneal cross-linking (CXL). Methods: Forty eyes of 35 patients underwent traditional or transepithelial CXL; there was randomization of 20 eyes to each group. By means of in vivo confocal microscopy and anterior segment ocular coherence tomography, we evaluated corneal alterations at 1 week, 1 month, and 3, 6, and 12 months after the treatment. Results: During follow-up, in vivo confocal microscopy showed a significant decrease in anterior keratocyte density (P = 0.001) and more evident stromal edema and keratocyte activation (P = 0.001) in the traditional group, whereas in the transepithelial group, no significant changes were observed (P > 0.05). Anterior segment ocular coherence tomography indicated the presence of hyperreflective stromal line significantly deeper and more persistent in the traditional group (P < 0.001). Conclusions: The preliminary results suggest that traditional CXL induced marked corneal modifications, which were poorly evident in the transepithelial group. |
| المشرفين على المادة: | 0 (Cross-Linking Reagents) 0 (Photosensitizing Agents) 9007-34-5 (Collagen) TLM2976OFR (Riboflavin) |
| تواريخ الأحداث: | Date Created: 20130330 Date Completed: 20130919 Latest Revision: 20131209 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/ICO.0b013e3182844c60 |
| PMID: | 23538618 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-4798 |
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| DOI: | 10.1097/ICO.0b013e3182844c60 |