دورية أكاديمية
Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology.
| العنوان: | Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology. |
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| المؤلفون: | Garcia-Arcos I; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., Hiyama Y; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., Drosatos K; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., Bharadwaj KG; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., Hu Y; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., Son NH; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., O'Byrne SM; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., Chang CL; Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032., Deckelbaum RJ; Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032., Takahashi M; Department of Medicine, Jichii University, Tochigi 329-0498, Japan., Westerterp M; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Medical Biochemistry, University of Amsterdam, 1105AZ Amsterdam, The Netherlands., Obunike JC; Department of Biological Sciences, New York City College of Technology, City University of New York, Brooklyn, New York 11201., Jiang H; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., Yagyu H; Department of Medicine, Jichii University, Tochigi 329-0498, Japan., Blaner WS; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032., Goldberg IJ; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032. Electronic address: ijg3@columbia.edu. |
| المصدر: | The Journal of biological chemistry [J Biol Chem] 2013 May 17; Vol. 288 (20), pp. 14046-14058. Date of Electronic Publication: 2013 Mar 31. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
| مواضيع طبية MeSH: | Adipose Tissue/*metabolism , Adipose Tissue, Brown/*metabolism , Adipose Tissue, White/*metabolism , Lipoprotein Lipase/*deficiency , Lipoprotein Lipase/*genetics, Adipocytes/cytology ; Animals ; Bone Marrow Transplantation ; Chylomicrons/pharmacokinetics ; Lipids/chemistry ; Lipolysis ; Macrophages/cytology ; Male ; Mice ; Mice, Knockout ; Phenotype ; Triglycerides/blood ; Triglycerides/metabolism |
| مستخلص: | Adipose fat storage is thought to require uptake of circulating triglyceride (TG)-derived fatty acids via lipoprotein lipase (LpL). To determine how LpL affects the biology of adipose tissue, we created adipose-specific LpL knock-out (ATLO) mice, and we compared them with whole body LpL knock-out mice rescued with muscle LpL expression (MCK/L0) and wild type (WT) mice. ATLO LpL mRNA and activity were reduced, respectively, 75 and 70% in gonadal adipose tissue (GAT), 90 and 80% in subcutaneous tissue, and 84 and 85% in brown adipose tissue (BAT). ATLO mice had increased plasma TG levels associated with reduced chylomicron TG uptake into BAT and lung. ATLO BAT, but not GAT, had altered TG composition. GAT from MCK/L0 was smaller and contained less polyunsaturated fatty acids in TG, although GAT from ATLO was normal unless LpL was overexpressed in muscle. High fat diet feeding led to less adipose in MCK/L0 mice but TG acyl composition in subcutaneous tissue and BAT reverted to that of WT. Therefore, adipocyte LpL in BAT modulates plasma lipoprotein clearance, and the greater metabolic activity of this depot makes its lipid composition more dependent on LpL-mediated uptake. Loss of adipose LpL reduces fat accumulation only if accompanied by greater LpL activity in muscle. These data support the role of LpL as the "gatekeeper" for tissue lipid distribution. |
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| معلومات مُعتمدة: | K99 HL112853 United States HL NHLBI NIH HHS; R01 HL045095 United States HL NHLBI NIH HHS; R37 HL045095 United States HL NHLBI NIH HHS; P30 DK026687 United States DK NIDDK NIH HHS; R01 DK068437 United States DK NIDDK NIH HHS; HL45095 United States HL NHLBI NIH HHS; T32 HL007343 United States HL NHLBI NIH HHS; R01 HL073029 United States HL NHLBI NIH HHS; R01 DK095684 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: Adipocyte; Fatty Acid; Hypertriglyceridemia; Lipids; Macrophages; Obesity |
| المشرفين على المادة: | 0 (Chylomicrons) 0 (Lipids) 0 (Triglycerides) EC 3.1.1.34 (Lipoprotein Lipase) |
| تواريخ الأحداث: | Date Created: 20130402 Date Completed: 20130806 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC3656262 |
| DOI: | 10.1074/jbc.M113.469270 |
| PMID: | 23542081 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1083-351X |
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| DOI: | 10.1074/jbc.M113.469270 |