دورية أكاديمية
أعرض في EDS

Biochemical and haematological assessment of toxic effects of the leaf ethanol extract of Petroselinum crispum (Mill) Nyman ex A.W. Hill (Parsley) in rats.

التفاصيل البيبلوغرافية
العنوان: Biochemical and haematological assessment of toxic effects of the leaf ethanol extract of Petroselinum crispum (Mill) Nyman ex A.W. Hill (Parsley) in rats.
المؤلفون: Awe EO; Department of Pharmacology & Therapeutics, College of Health Sciences, Ladoke, Akintola University of Technology, Ogbomoso, Nigeria. awemann@yahoo.co.uk, Banjoko SO
المصدر: BMC complementary and alternative medicine [BMC Complement Altern Med] 2013 Apr 04; Vol. 13, pp. 75. Date of Electronic Publication: 2013 Apr 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088661 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6882 (Electronic) Linking ISSN: 14726882 NLM ISO Abbreviation: BMC Complement Altern Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-2019]
مواضيع طبية MeSH: Kidney/*drug effects , Liver/*drug effects , Petroselinum/*chemistry , Plant Extracts/*chemistry , Plant Extracts/*toxicity, Alanine Transaminase/metabolism ; Alkaline Phosphatase/metabolism ; Animals ; Aspartate Aminotransferases/metabolism ; Blood Cell Count ; Hemoglobins/metabolism ; Kidney/metabolism ; Liver/enzymology ; Male ; Plant Leaves/chemistry ; Rats ; Rats, Wistar
مستخلص: Background: Petroselinum crispum, a bright green biennial shrub is widely used traditionally as a food additive and herbal remedies for many ailments. This study therefore aimed to assess the toxic effects of its leaf extract using some biochemical, haematological parameters.
Methods: The toxic effects were assessed by quantifying liver enzymes such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total serum protein and liver weight. Effects on haematological parameters were assessed by analysis of parked cell volume (PCV), red blood cell count (RBC), white blood cells (WBC) and haemoglobin (Hb) concentrations. Histopathological studies were done on the liver and kidneys.
Results: The extract caused significant increase in serum activity of alanine amino transferase and blood urea nitrogen (BUN) levels at the dose of 1000 mg/kg. Other biochemical and haematological parameters were not affected at lower doses. Conversely, the liver weight was not affected after eight weeks of treatment at the dose levels studied. The organs obtained for pathological study, were structurally unchanged under histopathological evaluation at lower doses but inflammatory and necrotic features were observed at doses ≥ 1000 mg/kg.
Conclusion: The results indicate that the leaf ethanol extract of Petroselinum crispum was hepatotoxic and nephrotoxic at continued oral doses equal to or more than 1000 mg/kg, but no obvious toxicity when used at lower doses. Therefore, there should be caution in its administration to avoid overdosing and known interaction with some medications. In addition, the plant should be kept away from pets and domestic animals and should not be cultivated on soil irrigated with waste water due to their ability to bio-accumulate toxic metals.
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المشرفين على المادة: 0 (Hemoglobins)
0 (Plant Extracts)
EC 2.6.1.1 (Aspartate Aminotransferases)
EC 2.6.1.2 (Alanine Transaminase)
EC 3.1.3.1 (Alkaline Phosphatase)
تواريخ الأحداث: Date Created: 20130406 Date Completed: 20130923 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3637085
DOI: 10.1186/1472-6882-13-75
PMID: 23557241
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6882
DOI:10.1186/1472-6882-13-75