دورية أكاديمية
Cavitation-enhanced delivery of a replicating oncolytic adenovirus to tumors using focused ultrasound.
| العنوان: | Cavitation-enhanced delivery of a replicating oncolytic adenovirus to tumors using focused ultrasound. |
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| المؤلفون: | Bazan-Peregrino M; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK. miriam.bazan-peregrino@balliol.oxon.org, Rifai B, Carlisle RC, Choi J, Arvanitis CD, Seymour LW, Coussios CC |
| المصدر: | Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2013 Jul 10; Vol. 169 (1-2), pp. 40-7. Date of Electronic Publication: 2013 Apr 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, 1984- |
| مواضيع طبية MeSH: | Adenoviridae/*physiology , Drug Delivery Systems/*instrumentation , Neoplasms/*therapy , Oncolytic Virotherapy/*instrumentation , Oncolytic Viruses/*physiology , Ultrasonics/*instrumentation, Adenoviridae/genetics ; Animals ; Cell Line, Tumor ; Equipment Design ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Microbubbles ; Neoplasms/genetics ; Oncolytic Viruses/genetics ; Transgenes |
| مستخلص: | Oncolytic viruses (OV) and ultrasound-enhanced drug delivery are powerful novel technologies. OV selectively self-amplify and kill cancer cells but their clinical use has been restricted by limited delivery from the bloodstream into the tumor. Ultrasound has been previously exploited for targeted release of OV in vivo, but its use to induce cavitation, microbubble oscillations, for enhanced OV tumor extravasation and delivery has not been previously reported. By identifying and optimizing the underlying physical mechanism, this work demonstrates that focused ultrasound significantly enhances the delivery and biodistribution of systemically administered OV co-injected with microbubbles. Up to a fiftyfold increase in tumor transgene expression was achieved, without any observable tissue damage. Ultrasound exposure parameters were optimized as a function of tumor reperfusion time to sustain inertial cavitation, a type of microbubble activity, throughout the exposure. Passive detection of acoustic emissions during treatment confirmed inertial cavitation as the mechanism responsible for enhanced delivery and enabled real-time monitoring of successful viral delivery. (Copyright © 2013 Elsevier B.V. All rights reserved.) |
| معلومات مُعتمدة: | 11339 United Kingdom CRUK_ Cancer Research UK; WT088877/Z/09/Z United Kingdom WT_ Wellcome Trust |
| تواريخ الأحداث: | Date Created: 20130409 Date Completed: 20140113 Latest Revision: 20220129 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jconrel.2013.03.017 |
| PMID: | 23562636 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4995 |
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| DOI: | 10.1016/j.jconrel.2013.03.017 |