دورية أكاديمية
Apolipoprotein E gene polymorphism and the risk of left ventricular dysfunction among Egyptian β-thalassemia major.
| العنوان: | Apolipoprotein E gene polymorphism and the risk of left ventricular dysfunction among Egyptian β-thalassemia major. |
|---|---|
| المؤلفون: | El-Tagui MH; Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt., Hamdy MM, Shaheen IA, Agha H, Abd-Elfatah HA |
| المصدر: | Gene [Gene] 2013 Jul 25; Vol. 524 (2), pp. 292-5. Date of Electronic Publication: 2013 Apr 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland, 1976- |
| مواضيع طبية MeSH: | Polymorphism, Genetic*, Apolipoprotein E4/*genetics , Ventricular Dysfunction, Left/*genetics , beta-Thalassemia/*genetics, Adolescent ; Adult ; Alleles ; Case-Control Studies ; Child ; Echocardiography ; Egypt/epidemiology ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Risk Factors ; Ventricular Dysfunction, Left/epidemiology ; Young Adult ; beta-Thalassemia/epidemiology |
| مستخلص: | In Egypt, β-thalassemia is the most common hereditary hemolytic anemia. Cardiac dysfunction, secondary to iron overload with formation of oxygen free radicals, is the most common cause of death in β-thalassemia patients. This study was designed to determine whether the allelic genotype of apolipoprotein E (Apo E), which exhibits antioxidant properties, could represent a genetic risk factor for the development of left ventricular (LV) dysfunction in β-thalassemia major. Fifty Egyptian β-thalassemia major patients were subjected to echocardiography to assess LV function. Apo E genotyping by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was done for all patients in addition to 50 age and sex matched healthy control subjects. Patients were classified into three groups. Group I and II were clinically asymptomatic. Group II subjects had evidence of LV dilatation, while Group III patients had clinical and echocardiographic findings of LV failure. Apo E4 allele was significantly higher among Group II and III than in controls. In conclusion, Apo E4 allele can be considered as a genetic risk factor for LV dysfunctions in β-thalassemic patients. It could be used as predictive indicator for additional risk of LV failure, particularly in asymptomatic patients with LV dilatation, requiring a closer follow-up, to prevent further disease progression. (Copyright © 2013 Elsevier B.V. All rights reserved.) |
| المشرفين على المادة: | 0 (Apolipoprotein E4) |
| تواريخ الأحداث: | Date Created: 20130418 Date Completed: 20130805 Latest Revision: 20130610 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.gene.2013.03.134 |
| PMID: | 23590983 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0038 |
|---|---|
| DOI: | 10.1016/j.gene.2013.03.134 |