دورية أكاديمية
Cytomegalovirus positive ulcerative colitis: A single center experience and literature review.
| العنوان: | Cytomegalovirus positive ulcerative colitis: A single center experience and literature review. |
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| المؤلفون: | Kopylov U; Uri Kopylov, Gila Sasson, Rami Eliakim, Shomron Ben-Horin, Department of Gastroenterology, Sheba Medical Center, Ramat Gan 52621, Israel., Sasson G, Geyshis B, Oikawa MT, Barshack I, Eliakim R, Ben-Horin S |
| المصدر: | World journal of gastrointestinal pathophysiology [World J Gastrointest Pathophysiol] 2013 Feb 15; Vol. 4 (1), pp. 18-23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101547471 Publication Model: Print Cited Medium: Print ISSN: 2150-5330 (Print) Linking ISSN: 21505330 NLM ISO Abbreviation: World J Gastrointest Pathophysiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing, China : Beijing Baishideng BioMed Scientifc Company |
| مستخلص: | Aim: To compare the clinical outcome of cytomegalovirus (CMV)-positive ulcerative colitis (UC) patients with and without antiviral therapy. Methods: This was a retrospective case-controlled study. The database of UC patients in our institution was scanned for documented presence of CMV on colonic biopsies. Demographics, clinical data, endoscopy findings and pathology reports were extracted from the patients' charts and electronic records. When available, the data from colonoscopies preceding and following the diagnosis of colonic CMV infection were also extracted. The primary outcomes of the study were colectomy/death during hospitalization and the secondary outcomes were colectomy/death through the course of the follow-up. Results: Thirteen patients were included in the study, 7 (53.5%) of them were treated with gancyclovir and 6 (46.5%) were not. Patients treated with antivirals presented with a more severe disease and 57% of them were treated with cyclosporine or infliximab before initiation of gancyclovir, while none of the patients without antivirals required rescue therapy. One patient died and another patient underwent urgent colectomy during hospitalization, both of them from the gancyclovir-treatment group. For the entire follow-up time (13 ± 13 mo), a total of 3 colectomies and one death occurred, all among the antiviral-treated patients (for colectomy: 3/7 vs 0/6 patients, P = 0.19; for combined adverse outcome: 4/7 vs 0/6 patients, P = 0.07). In 9/13 patients, immunohistochemistry for CMV was performed on biopsies obtained during a subsequent colonoscopy and was positive in one patient only. Conclusion: Gancyclovir-treated patients had a more severe disease and outcome, probably unrelated to antiviral therapy. Immunohistochemistry-CMV-positive patients with mild disease may recover without antiviral therapy. |
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| فهرسة مساهمة: | Keywords: Cyclosporine; Cytomegalovirus; Gancyclovir; Immunohistochemistry; Ulcerative colitis |
| تواريخ الأحداث: | Date Created: 20130419 Date Completed: 20130419 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3627461 |
| DOI: | 10.4291/wjgp.v4.i1.18 |
| PMID: | 23596551 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2150-5330 |
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| DOI: | 10.4291/wjgp.v4.i1.18 |