دورية أكاديمية
[Increase of general toxic effects and decrease of hepatocarcinogenic effects of diethylnitrosamine administered to mice in conjunction with isopropanol].
| العنوان: | [Increase of general toxic effects and decrease of hepatocarcinogenic effects of diethylnitrosamine administered to mice in conjunction with isopropanol]. |
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| المؤلفون: | Kaledin VI, Baginskaia NV, Vasiunina EA, Il'nitskaia SI, Ovchinnikova LP |
| المصدر: | Voprosy onkologii [Vopr Onkol] 2012; Vol. 58 (5), pp. 658-62. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Nauchno-issledovatelʹskiĭ institut onkologii im. N.N. Petrova Country of Publication: Russia (Federation) NLM ID: 0413775 Publication Model: Print Cited Medium: Print ISSN: 0507-3758 (Print) Linking ISSN: 05073758 NLM ISO Abbreviation: Vopr Onkol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013-: St Petersburg : Nauchno-issledovatelʹskiĭ institut onkologii im. N.N. Petrova Original Publication: St Petersburg : Izdatelstvo Meditsina, Leningradskoe Otdelenie |
| مواضيع طبية MeSH: | 2-Propanol/*toxicity , Alkylating Agents/*toxicity , Carcinogens/*toxicity , Diethylnitrosamine/*toxicity , Liver Neoplasms, Experimental/*chemically induced , Microsomes, Liver/*enzymology, 2-Propanol/administration & dosage ; Alkylating Agents/administration & dosage ; Animals ; Carcinogens/administration & dosage ; Cytochrome P-450 CYP2E1/metabolism ; DNA Damage/drug effects ; Diethylnitrosamine/administration & dosage ; Liver Neoplasms, Experimental/metabolism ; Male ; Mice ; Mice, Inbred ICR ; Microsomes, Liver/metabolism |
| مستخلص: | It is considered that diethylnitrosamine (DENA) is metabolized mostly in the liver with producing highly reactive compounds alkylating cellular macromolecules and causing toxic and carcinogenic effects. However, competitive inhibition of cytochrome P450 2E1, which metabolizes DENA, by its other substrate, isopropanol, does not weaken, but enhances the toxicity of DENA effect on mice and reduces the number of preneoplastic nodules and liver tumors induced by it. In short-term tests for mutagenicity (in the Ames test and the SOS-hromotest) DENA causes moderate damage of DNA that reduces liver microsomal enzymes, that metabolize nitrosamines. The obtained data indicate the predominant role of the initial compound as compared to its metabolites in toxic, and probably hepatocarcinogenic, effects on DNA in mice. |
| المشرفين على المادة: | 0 (Alkylating Agents) 0 (Carcinogens) 3IQ78TTX1A (Diethylnitrosamine) EC 1.14.13.- (Cytochrome P-450 CYP2E1) ND2M416302 (2-Propanol) |
| تواريخ الأحداث: | Date Created: 20130423 Date Completed: 20130520 Latest Revision: 20141120 |
| رمز التحديث: | 20231215 |
| PMID: | 23600284 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0507-3758 |
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