دورية أكاديمية
أعرض في EDS

Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm.

التفاصيل البيبلوغرافية
العنوان: Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm.
المؤلفون: Sabelli PA; School of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA. psabelli@ag.arizona.edu, Liu Y, Dante RA, Lizarraga LE, Nguyen HN, Brown SW, Klingler JP, Yu J, LaBrant E, Layton TM, Feldman M, Larkins BA
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 May 07; Vol. 110 (19), pp. E1827-36. Date of Electronic Publication: 2013 Apr 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Arabidopsis Proteins/*metabolism , Endosperm/*physiology , Retinoblastoma Protein/*metabolism , Zea mays/*metabolism, Cell Cycle ; Cell Death ; Cell Proliferation ; Cyclin-Dependent Kinases/metabolism ; Gene Expression Regulation, Plant ; Genotype ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; RNA Interference ; Seeds/physiology ; Zea mays/genetics
مستخلص: The endosperm of cereal grains is one of the most valuable products of modern agriculture. Cereal endosperm development comprises different phases characterized by mitotic cell proliferation, endoreduplication, the accumulation of storage compounds, and programmed cell death. Although manipulation of these processes could maximize grain yield, how they are regulated and integrated is poorly understood. We show that the Retinoblastoma-related (RBR) pathway controls key aspects of endosperm development in maize. Down-regulation of RBR1 by RNAi resulted in up-regulation of RBR3-type genes, as well as the MINICHROMOSOME MAINTENANCE 2-7 gene family and PROLIFERATING CELL NUCLEAR ANTIGEN, which encode essential DNA replication factors. Both the mitotic and endoreduplication cell cycles were stimulated. Developing transgenic endosperm contained 42-58% more cells and ∼70% more DNA than wild type, whereas there was a reduction in cell and nuclear sizes. In addition, cell death was enhanced. The DNA content of mature endosperm increased 43% upon RBR1 down-regulation, whereas storage protein content and kernel weight were essentially not affected. Down-regulation of both RBR1 and CYCLIN DEPENDENT KINASE A (CDKA);1 indicated that CDKA;1 is epistatic to RBR1 and controls endoreduplication through an RBR1-dependent pathway. However, the repressive activity of RBR1 on downstream targets was independent from CDKA;1, suggesting diversification of RBR1 activities. Furthermore, RBR1 negatively regulated CDK activity, suggesting the presence of a feedback loop. These results indicate that the RBR1 pathway plays a major role in regulation of different processes during maize endosperm development and suggest the presence of tissue/organ-level regulation of endosperm/seed homeostasis.
References: Gynecol Oncol. 2011 Apr;121(1):24-31. (PMID: 21251700)
FEBS Lett. 2004 Jun 1;567(1):152-7. (PMID: 15165909)
Cell Cycle. 2006 Feb;5(4):352-5. (PMID: 16479170)
Science. 1995 Sep 1;269(5228):1262-4. (PMID: 17732113)
Nat Rev Mol Cell Biol. 2008 Sep;9(9):713-24. (PMID: 18719710)
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13005-12. (PMID: 16141340)
Plant Cell. 2003 Feb;15(2):303-15. (PMID: 12566574)
Plant Physiol. 2006 Jan;140(1):67-80. (PMID: 16361519)
Ann Bot. 2011 May;107(7):1159-69. (PMID: 21199834)
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18729-34. (PMID: 20937895)
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3377-81. (PMID: 2014258)
Plant Cell. 2006 Feb;18(2):382-96. (PMID: 16415207)
Nature. 2003 Jul 10;424(6945):223-8. (PMID: 12853964)
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20219-24. (PMID: 22123962)
J Cell Biol. 1995 Feb;128(4):467-83. (PMID: 7532171)
Plant Mol Biol. 2003 Feb;51(3):401-13. (PMID: 12602870)
Plant Cell. 2005 Jun;17(6):1723-36. (PMID: 15863515)
J Cell Sci. 2009 May 15;122(Pt 10):1477-86. (PMID: 19420234)
Plant Cell. 2004 Feb;16(2):510-22. (PMID: 14729913)
Development. 2012 Oct;139(20):3817-26. (PMID: 22991446)
PLoS Biol. 2008 Aug 12;6(8):e194. (PMID: 18700816)
Genes Dev. 2009 Nov 1;23(21):2461-77. (PMID: 19884253)
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4042-7. (PMID: 19234120)
PLoS Genet. 2010 Jun 17;6(6):e1000988. (PMID: 20585548)
Cell. 2008 May 2;133(3):523-36. (PMID: 18423832)
Oncogene. 2005 Apr 18;24(17):2796-809. (PMID: 15838516)
Annu Rev Genet. 2006;40:77-105. (PMID: 17094738)
Plant Cell. 2011 Dec;23(12):4221-33. (PMID: 22198147)
Plant Cell. 2002 Aug;14(8):1847-57. (PMID: 12172026)
Mol Cell Biol. 2002 Apr;22(7):2124-35. (PMID: 11884600)
Nucleic Acids Res. 2000 Sep 1;28(17):3250-9. (PMID: 10954592)
Development. 2010 Jan;137(1):63-71. (PMID: 20023161)
Nat Genet. 2007 Jan;39(1):61-9. (PMID: 17128275)
Plant Cell. 2004 Jul;16(7):1854-69. (PMID: 15208390)
EMBO J. 1996 Nov 15;15(22):6178-88. (PMID: 8947040)
Science. 2009 Jun 12;324(5933):1447-51. (PMID: 19520961)
Plant Mol Biol. 2000 Oct;44(3):283-301. (PMID: 11199389)
Plant Cell. 1993 Dec;5(12):1711-23. (PMID: 8305869)
Plant Mol Biol. 2007 Sep;65(1-2):163-75. (PMID: 17634748)
Cancer Res. 2001 Dec 1;61(23):8395-400. (PMID: 11731416)
Mol Syst Biol. 2010 Aug 10;6:397. (PMID: 20706207)
Sex Plant Reprod. 2009 Dec;22(4):207-19. (PMID: 20033442)
Proc Natl Acad Sci U S A. 1985 Oct;82(20):7010-4. (PMID: 16593620)
J Cell Sci. 2002 Mar 1;115(Pt 5):973-82. (PMID: 11870216)
Plant Physiol. 2009 Jan;149(1):14-26. (PMID: 19126691)
Plant Mol Biol. 2008 Feb;66(3):259-75. (PMID: 18064404)
J Exp Bot. 2001 Feb;52(355):183-92. (PMID: 11283162)
Ann Bot. 2005 Jan;95(1):147-75. (PMID: 15596464)
Plant Cell. 2010 Jun;22(6):1792-811. (PMID: 20525851)
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8962-7. (PMID: 8799136)
Plant J. 2001 Nov;28(3):341-50. (PMID: 11722776)
EMBO J. 2002 Mar 15;21(6):1360-8. (PMID: 11889041)
Plant Cell. 2001 Oct;13(10):2297-317. (PMID: 11595803)
Plant Physiol. 2005 Aug;138(4):2323-36. (PMID: 16055680)
Dev Cell. 2012 May 15;22(5):1030-40. (PMID: 22595674)
Plant J. 2005 Apr;42(2):153-63. (PMID: 15807779)
Science. 2009 Jun 12;324(5933):1451-4. (PMID: 19520962)
Cell. 2001 May 4;105(3):297-306. (PMID: 11348589)
PLoS Biol. 2010 Nov 02;8(11):e1000523. (PMID: 21072241)
Curr Opin Plant Biol. 2003 Dec;6(6):544-53. (PMID: 14611952)
Mol Cell. 1998 Sep;2(3):293-304. (PMID: 9774968)
فهرسة مساهمة: Keywords: endocycle; seed development
المشرفين على المادة: 0 (Arabidopsis Proteins)
0 (RBR1 protein, Arabidopsis)
0 (Retinoblastoma Protein)
EC 2.7.11.22 (CDKA1 protein, Arabidopsis)
EC 2.7.11.22 (Cyclin-Dependent Kinases)
تواريخ الأحداث: Date Created: 20130424 Date Completed: 20130719 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3651506
DOI: 10.1073/pnas.1304903110
PMID: 23610440
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.1304903110