دورية أكاديمية
Assuring safety without animal testing: the case for the human testis in vitro.
| العنوان: | Assuring safety without animal testing: the case for the human testis in vitro. |
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| المؤلفون: | Chapin RE; Drug Safety R&D, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. robert.e.chapin@pfizer.com, Boekelheide K, Cortvrindt R, van Duursen MB, Gant T, Jegou B, Marczylo E, van Pelt AM, Post JN, Roelofs MJ, Schlatt S, Teerds KJ, Toppari J, Piersma AH |
| المصدر: | Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2013 Aug; Vol. 39, pp. 63-8. Date of Electronic Publication: 2013 Apr 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Elmsford Ny : Pergamon In Cooperation With The Reproductive Toxicology Center Original Publication: Elmsford, N.Y., U.S.A. : Pergamon Press, c1987- |
| مواضيع طبية MeSH: | Animal Testing Alternatives*, Testis/*cytology , Toxicity Tests/*methods, Animals ; Cell Culture Techniques ; Humans ; Male ; Tissue Engineering |
| مستخلص: | From 15 to 17 June 2011, a dedicated workshop was held on the subject of in vitro models for mammalian spermatogenesis and their applications in toxicological hazard and risk assessment. The workshop was sponsored by the Dutch ASAT initiative (Assuring Safety without Animal Testing), which aims at promoting innovative approaches toward toxicological hazard and risk assessment on the basis of human and in vitro data, and replacement of animal studies. Participants addressed the state of the art regarding human and animal evidence for compound mediated testicular toxicity, reviewed existing alternative assay models, and brainstormed about future approaches, specifically considering tissue engineering. The workshop recognized the specific complexity of testicular function exemplified by dedicated cell types with distinct functionalities, as well as different cell compartments in terms of microenvironment and extracellular matrix components. This complexity hampers quick results in the realm of alternative models. Nevertheless, progress has been achieved in recent years, and innovative approaches in tissue engineering may open new avenues for mimicking testicular function in vitro. Although feasible, significant investment is deemed essential to be able to bring new ideas into practice in the laboratory. For the advancement of in vitro testicular toxicity testing, one of the most sensitive end points in regulatory reproductive toxicity testing, such an investment is highly desirable. (Copyright © 2013. Published by Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20130425 Date Completed: 20140109 Latest Revision: 20130614 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.reprotox.2013.04.004 |
| PMID: | 23612449 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-1708 |
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| DOI: | 10.1016/j.reprotox.2013.04.004 |