دورية أكاديمية
GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population.
| العنوان: | GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population. |
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| المؤلفون: | Chen YP; Department of Neurology, West China Hospital, SiChuan University, Chengdu Sichuan, China., Song W, Huang R, Chen K, Zhao B, Li J, Yang Y, Shang HF |
| المصدر: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2013 Jun; Vol. 20 (6), pp. 880-3. Date of Electronic Publication: 2013 Apr 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 9433352 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2653 (Electronic) Linking ISSN: 09675868 NLM ISO Abbreviation: J Clin Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Edinburgh : Churchill Livingstone Original Publication: Melbourne, Vic., Australia : Churchill Livingstone, c1994- |
| مواضيع طبية MeSH: | Genetic Predisposition to Disease*, Diacylglycerol Kinase/*genetics , Intracellular Signaling Peptides and Proteins/*genetics , Parkinson Disease/*genetics , Polymorphism, Single Nucleotide/*genetics , Protein Serine-Threonine Kinases/*genetics, Asian People/genetics ; China/epidemiology ; Female ; Gene Frequency ; Genetic Association Studies ; Genotype ; Humans ; Male ; Parkinson Disease/ethnology ; Retrospective Studies |
| مستخلص: | Numerous single-nucleotide polymorphisms (SNPs) such as GAK rs1564282 and DGKQ rs11248060 have been reported to be associated with the risk of Parkinson's disease (PD) in Caucasian populations. However, this association is yet to be proven in the Chinese population. This study included 376 unrelated Han Chinese PD patients from Southwest China and 277 unrelated Chinese healthy controls from the same region. Two SNPs, namely, rs1564282 and rs11248060, were genotyped using Sequenom's iPLEX assay. The allele frequencies and genotype distributions of the SNPs in the PD patients and controls were compared using Fisher's exact test. Significant differences were found in the genotype distributions and allele frequencies for DGKQ rs11248060 between PD patients and controls (p = 0.0425 and p = 0.0308, respectively). Significant differences were also observed in the allele frequencies for GAK rs1564282 between PD patients and controls. No significant differences were observed in the genotype frequencies, minor allele frequency, and minor allele carrier frequencies between early-onset PD (EOPD) and controls, between late-onset PD (LOPD) and controls, and between EOPD and LOPD after conservative Bonferroni adjustment. GAK rs1564282 and DGKQ rs11248060 increase the risk for PD in Chinese patients. More related studies with a larger number of participants are needed to confirm these findings. (Copyright © 2012 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Intracellular Signaling Peptides and Proteins) EC 2.7.1.107 (Diacylglycerol Kinase) EC 2.7.11.1 (GAK protein, human) EC 2.7.11.1 (Protein Serine-Threonine Kinases) |
| تواريخ الأحداث: | Date Created: 20130427 Date Completed: 20140109 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jocn.2012.07.011 |
| PMID: | 23618683 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2653 |
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| DOI: | 10.1016/j.jocn.2012.07.011 |