دورية أكاديمية
Intranasal administration of antibody-bound respiratory syncytial virus particles efficiently primes virus-specific immune responses in mice.
العنوان: | Intranasal administration of antibody-bound respiratory syncytial virus particles efficiently primes virus-specific immune responses in mice. |
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المؤلفون: | Kruijsen D; Department of Pediatrics, the Wilhelmina Children's Hospital, University Medical Center (UMC), Utrecht, The Netherlands., Einarsdottir HK, Schijf MA, Coenjaerts FE, van der Schoot EC, Vidarsson G, van Bleek GM |
المصدر: | Journal of virology [J Virol] 2013 Jul; Vol. 87 (13), pp. 7550-7. Date of Electronic Publication: 2013 May 01. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
مواضيع طبية MeSH: | Adaptive Immunity/*immunology , Antibodies, Neutralizing/*immunology , Respiratory Syncytial Virus Infections/*immunology , Respiratory Syncytial Viruses/*immunology , Virion/*immunology, Administration, Intranasal ; Analysis of Variance ; Animals ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/genetics ; Cytokines/immunology ; DNA Primers ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Histocompatibility Antigens Class I/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Picrates ; Real-Time Polymerase Chain Reaction ; Receptors, Fc/genetics ; Respiratory Syncytial Viruses/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Virion/genetics |
مستخلص: | Infants are protected from a severe respiratory syncytial virus (RSV) infection in the first months of life by maternal antibodies or by prophylactically administered neutralizing antibodies. Efforts are under way to produce RSV-specific antibodies with increased neutralizing capacity compared to the currently licensed palivizumab. While clearly beneficial during primary infections, preexisting antibodies might affect the onset of adaptive immune responses and the ability to resist subsequent RSV infections. Therefore, we addressed the question of how virus neutralizing antibodies influence the priming of subsequent adaptive immune responses. To test a possible role of the neonatal Fc receptor (FcRn) in this process, we compared the responses in C57BL/6 wild-type (WT) and FcRn(-/-) mice. We observed substantial virus-specific T-cell priming and B-cell responses in mice primed with RSV IgG immune complexes resulting in predominantly Th1-type CD4(+) T-cell and IgG2c antibody responses upon live-virus challenge. RSV-specific CD8(+) T cells were primed as well. Activation of these adaptive immune responses was independent of FcRn. Thus, neutralizing antibodies that localize to the airways and prevent infection-related routes of antigen processing can still facilitate antigen presentation of neutralized virus particles and initiate adaptive immune responses against RSV. |
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المشرفين على المادة: | 0 (Antibodies, Neutralizing) 0 (Cytokines) 0 (DNA Primers) 0 (Histocompatibility Antigens Class I) 0 (Picrates) 0 (Receptors, Fc) A49OS0F91S (picric acid) TW3XAW0RCY (Fc receptor, neonatal) |
تواريخ الأحداث: | Date Created: 20130503 Date Completed: 20130812 Latest Revision: 20240514 |
رمز التحديث: | 20240514 |
مُعرف محوري في PubMed: | PMC3700286 |
DOI: | 10.1128/JVI.00493-13 |
PMID: | 23637394 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1098-5514 |
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DOI: | 10.1128/JVI.00493-13 |