دورية أكاديمية
Intranasal administration of antibody-bound respiratory syncytial virus particles efficiently primes virus-specific immune responses in mice.
| العنوان: | Intranasal administration of antibody-bound respiratory syncytial virus particles efficiently primes virus-specific immune responses in mice. |
|---|---|
| المؤلفون: | Kruijsen D; Department of Pediatrics, the Wilhelmina Children's Hospital, University Medical Center (UMC), Utrecht, The Netherlands., Einarsdottir HK, Schijf MA, Coenjaerts FE, van der Schoot EC, Vidarsson G, van Bleek GM |
| المصدر: | Journal of virology [J Virol] 2013 Jul; Vol. 87 (13), pp. 7550-7. Date of Electronic Publication: 2013 May 01. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
| مواضيع طبية MeSH: | Adaptive Immunity/*immunology , Antibodies, Neutralizing/*immunology , Respiratory Syncytial Virus Infections/*immunology , Respiratory Syncytial Viruses/*immunology , Virion/*immunology, Administration, Intranasal ; Analysis of Variance ; Animals ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/genetics ; Cytokines/immunology ; DNA Primers ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Histocompatibility Antigens Class I/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Picrates ; Real-Time Polymerase Chain Reaction ; Receptors, Fc/genetics ; Respiratory Syncytial Viruses/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Virion/genetics |
| مستخلص: | Infants are protected from a severe respiratory syncytial virus (RSV) infection in the first months of life by maternal antibodies or by prophylactically administered neutralizing antibodies. Efforts are under way to produce RSV-specific antibodies with increased neutralizing capacity compared to the currently licensed palivizumab. While clearly beneficial during primary infections, preexisting antibodies might affect the onset of adaptive immune responses and the ability to resist subsequent RSV infections. Therefore, we addressed the question of how virus neutralizing antibodies influence the priming of subsequent adaptive immune responses. To test a possible role of the neonatal Fc receptor (FcRn) in this process, we compared the responses in C57BL/6 wild-type (WT) and FcRn(-/-) mice. We observed substantial virus-specific T-cell priming and B-cell responses in mice primed with RSV IgG immune complexes resulting in predominantly Th1-type CD4(+) T-cell and IgG2c antibody responses upon live-virus challenge. RSV-specific CD8(+) T cells were primed as well. Activation of these adaptive immune responses was independent of FcRn. Thus, neutralizing antibodies that localize to the airways and prevent infection-related routes of antigen processing can still facilitate antigen presentation of neutralized virus particles and initiate adaptive immune responses against RSV. |
| References: | J Infect Dis. 2003 Apr 15;187(8):1257-63. (PMID: 12696005) Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9337-42. (PMID: 18599440) J Exp Med. 2002 Sep 16;196(6):859-65. (PMID: 12235218) J Infect Dis. 1997 Nov;176(5):1215-24. (PMID: 9359721) J Immunol Methods. 2001 Mar 1;249(1-2):245-52. (PMID: 11226481) Int Immunol. 1999 Jun;11(6):979-86. (PMID: 10360972) J Med Virol. 2010 Jul;82(7):1266-71. (PMID: 20513094) Clin Vaccine Immunol. 2010 Dec;17(12):1829-35. (PMID: 20876821) Int Immunol. 2001 Dec;13(12):1551-9. (PMID: 11717196) J Exp Med. 2002 Aug 5;196(3):303-10. (PMID: 12163559) J Exp Med. 2003 Feb 3;197(3):315-22. (PMID: 12566415) Blood. 2006 Nov 15;108(10):3573-9. (PMID: 16849638) Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9927-32. (PMID: 21628593) J Immunol. 2000 Jun 15;164(12):6113-9. (PMID: 10843660) Pediatrics. 2010 Jan;125(1):e35-51. (PMID: 20008423) Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9763-8. (PMID: 15210944) J Exp Med. 1999 Jan 18;189(2):371-80. (PMID: 9892619) J Gen Virol. 2008 Jan;89(Pt 1):261-270. (PMID: 18089750) J Clin Microbiol. 2002 Mar;40(3):817-20. (PMID: 11880399) Immunity. 2004 Jun;20(6):769-83. (PMID: 15189741) J Immunol Methods. 1998 Mar 15;212(2):187-92. (PMID: 9672206) J Immunol. 2011 Apr 15;186(8):4674-86. (PMID: 21402891) Virology. 2006 Aug 15;352(1):157-68. (PMID: 16730775) Cell Immunol. 1980 Feb;49(2):408-14. (PMID: 6243516) Clin Diagn Lab Immunol. 1996 May;3(3):280-6. (PMID: 8705669) J Exp Med. 1992 Dec 1;176(6):1693-702. (PMID: 1460426) J Virol. 2007 Sep;81(17):9443-50. (PMID: 17596309) J Immunol. 2008 Dec 1;181(11):7550-61. (PMID: 19017944) J Virol. 2009 Jul;83(14):7235-43. (PMID: 19420085) J Infect Dis. 1991 Apr;163(4):693-8. (PMID: 2010624) Eur J Immunol. 1999 Sep;29(9):2819-25. (PMID: 10508256) Nat Commun. 2011 Dec 20;2:599. (PMID: 22186895) Vaccine. 2003 Jul 28;21(24):3479-82. (PMID: 12850364) J Immunol. 2010 Dec 1;185(11):6489-98. (PMID: 20971927) Am J Dis Child. 1986 Jun;140(6):543-6. (PMID: 3706232) Pediatrics. 1998 Sep;102(3):531-7. (PMID: 9724660) J Immunol. 1997 Mar 1;158(5):2211-7. (PMID: 9036967) J Infect Dis. 1994 Jun;169(6):1368-73. (PMID: 8195619) Cell. 1994 Feb 11;76(3):519-29. (PMID: 8313472) Immunity. 2002 Mar;16(3):391-402. (PMID: 11911824) J Med Virol. 1997 May;52(1):97-104. (PMID: 9131465) Nat Biotechnol. 2011 Feb;29(2):158-63. (PMID: 21240266) Vaccine. 2011 Mar 24;29(15):2730-41. (PMID: 21316502) PLoS One. 2007 Sep 19;2(9):e898. (PMID: 17878933) J Immunol. 2002 Mar 1;168(5):2240-6. (PMID: 11859111) J Immunol. 2002 Nov 1;169(9):5171-80. (PMID: 12391234) Eur J Immunol. 1987 Mar;17(3):375-83. (PMID: 3494611) |
| المشرفين على المادة: | 0 (Antibodies, Neutralizing) 0 (Cytokines) 0 (DNA Primers) 0 (Histocompatibility Antigens Class I) 0 (Picrates) 0 (Receptors, Fc) A49OS0F91S (picric acid) TW3XAW0RCY (Fc receptor, neonatal) |
| تواريخ الأحداث: | Date Created: 20130503 Date Completed: 20130812 Latest Revision: 20240514 |
| رمز التحديث: | 20240514 |
| مُعرف محوري في PubMed: | PMC3700286 |
| DOI: | 10.1128/JVI.00493-13 |
| PMID: | 23637394 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-5514 |
|---|---|
| DOI: | 10.1128/JVI.00493-13 |