دورية أكاديمية
Prolonged survival of patients with breast cancer-related leptomeningeal metastases.
| العنوان: | Prolonged survival of patients with breast cancer-related leptomeningeal metastases. |
|---|---|
| المؤلفون: | Le Rhun E; Breast unit, Department of Medical Oncology, Oscar Lambret Center, Lille Cedex, France. E-lerhun@o-lambret.fr, Taillibert S, Zairi F, Pannier D, Boulanger T, Andre C, Cazin JL, Dubois F, Bonneterre J, Chamberlain MC |
| المصدر: | Anticancer research [Anticancer Res] 2013 May; Vol. 33 (5), pp. 2057-63. |
| نوع المنشور: | Clinical Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Attiki, Greece : International Institute of Anticancer Research Original Publication: Athens, Greece : Potamitis Press |
| مواضيع طبية MeSH: | Breast Neoplasms/*mortality , Carcinoma, Ductal, Breast/*mortality , Carcinoma, Lobular/*mortality , Meningeal Neoplasms/*mortality, Adult ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/therapy ; Carcinoma, Lobular/pathology ; Carcinoma, Lobular/therapy ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Meningeal Neoplasms/secondary ; Meningeal Neoplasms/therapy ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Survival Rate |
| مستخلص: | Background/aim: Prolonged overall survival (OS) has been reported for selected patients with leptomeningeal metastases (LM). The management and treatment of such patients is poorly-described. We report our experience on breast cancer (BC)-associated LM and patients with prolonged survival. Patients and Methods: Eleven patients with BC and LM had an OS >12 months in which treatment is described. Results: Combined intra-cerebro spinal fluid (CSF) and systemic treatment were administered until disease progression or toxicity in all but two patients. Involved-field radiotherapy was administered to two patients. Median OS in this selected cohort following LM diagnosis, was 21.0 (range=13-33.3) months. Conclusion: Prolonged OS but also prolonged responses can be observed in BC with LM. An individualized and multi-disciplinary approach is advised for the management of these patients. |
| فهرسة مساهمة: | Keywords: Leptomeningeal metastases; breast cancer; intra-CSF chemotherapy; liposomal cytarabine; multimodality treatment; neoplastic meningitis |
| تواريخ الأحداث: | Date Created: 20130507 Date Completed: 20130626 Latest Revision: 20130506 |
| رمز التحديث: | 20240628 |
| PMID: | 23645756 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1791-7530 |
|---|