دورية أكاديمية
Mutagenic activation reduces carcinogenic activity of ortho-aminoazotoluene for mouse liver.
| العنوان: | Mutagenic activation reduces carcinogenic activity of ortho-aminoazotoluene for mouse liver. |
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| المؤلفون: | Ovchinnikova LP; Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Bogdanova LA, Kaledin VI |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Mar; Vol. 154 (5), pp. 664-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | Carcinogenesis*, Carcinogens/*metabolism , Liver/*drug effects , Liver/*metabolism , Pentachlorophenol/*pharmacology , o-Aminoazotoluene/*metabolism, Animals ; Carcinogenicity Tests ; Carcinogens/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Inbred ICR ; Mutagenicity Tests ; Pentachlorophenol/chemistry ; Pentachlorophenol/metabolism ; o-Aminoazotoluene/chemistry ; o-Aminoazotoluene/toxicity |
| مستخلص: | Pentachlorophenol (aromatic amine and azo stain metabolic stimulation inhibitor) reduced the hepatocarcinogenic activity of 4-aminoazobenzene and reduced that of ortho-aminoazotoluene in suckling mice. Both 4-aminoazobenzene and ortho-aminoazotoluene exhibited mutagenic activity in Ames' test in vitro on S. typhimurium TA 98 strain with activation with liver enzymes; this mutagenic activity was similarly suppressed by adding pentachlorophenol into activation medium. Induction of xenobiotic metabolism enzymes, stimulating the mutagenic activity of ortho-aminoazotoluene, suppressed its carcinogenic effect on mouse liver. Hence, ortho-aminotoluene (the initial compound), but not its mutagenic metabolites, was the direct active hepatocarcinogen for mice. |
| المشرفين على المادة: | 0 (Carcinogens) D9BSU0SE4T (Pentachlorophenol) QHZ900P7ZA (o-Aminoazotoluene) |
| تواريخ الأحداث: | Date Created: 20130510 Date Completed: 20140218 Latest Revision: 20190813 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10517-013-2025-4 |
| PMID: | 23658894 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-8221 |
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| DOI: | 10.1007/s10517-013-2025-4 |