دورية أكاديمية
أعرض في EDS

Combined diffusion-weighted, blood oxygen level-dependent, and dynamic contrast-enhanced MRI for characterization and differentiation of renal cell carcinoma.

التفاصيل البيبلوغرافية
العنوان: Combined diffusion-weighted, blood oxygen level-dependent, and dynamic contrast-enhanced MRI for characterization and differentiation of renal cell carcinoma.
المؤلفون: Notohamiprodjo M; Department of Clinical Radiology, University Hospitals Munich, Marchioninistrasse 15, 81377 Munich, Germany. mike.notohamiprodjo@med.uni-muenchen.de, Staehler M, Steiner N, Schwab F, Sourbron SP, Michaely HJ, Helck AD, Reiser MF, Nikolaou K
المصدر: Academic radiology [Acad Radiol] 2013 Jun; Vol. 20 (6), pp. 685-93.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Association Of University Radiologists Country of Publication: United States NLM ID: 9440159 Publication Model: Print Cited Medium: Internet ISSN: 1878-4046 (Electronic) Linking ISSN: 10766332 NLM ISO Abbreviation: Acad Radiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Reston Va : Association Of University Radiologists
Original Publication: Reston, VA : Association of University Radiologists, c1994-
مواضيع طبية MeSH: Carcinoma, Renal Cell/*metabolism , Carcinoma, Renal Cell/*pathology , Diffusion Magnetic Resonance Imaging/*methods , Kidney Neoplasms/*metabolism , Kidney Neoplasms/*pathology , Magnetic Resonance Angiography/*methods , Oxygen/*blood, Contrast Media ; Female ; Humans ; Male ; Middle Aged ; Oximetry/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Subtraction Technique
مستخلص: Purpose: To investigate a multiparametric magnetic resonance imaging (MRI) approach comprising diffusion-weighted imaging (DWI), blood oxygen-dependent (BOLD), and dynamic contrast-enhanced (DCE) MRI for characterization and differentiation of primary renal cell carcinoma (RCC).
Material and Methods: Fourteen patients with clear-cell carcinoma and four patients with papillary RCC were examined with DWI, BOLD MRI, and DCE MRI at 1.5T. The apparent diffusion coefficient (ADC) was calculated with a monoexponential decay. The spin-dephasing rate R2* was derived from parametric R2* maps. DCE-MRI was analyzed using a two-compartment exchange model allowing separation of perfusion (plasma flow [FP] and plasma volume [VP]), permeability (permeability surface area product [PS]), and extravascular extracellular volume (VE). Statistical analysis was performed with Wilcoxon signed-rank test, Pearson's correlation coefficient, and receiver operating characteristic curve analysis.
Results: Clear-cell RCC showed higher ADC and lower R2* compared to papillary subtypes, but differences were not significant. FP of clear-cell subtypes was significantly higher than in papillary RCC. Perfusion parameters showed moderate but significant inverse correlation with R2*. VE showed moderate inverse correlation with ADC. Fp and Vp showed best sensitivity for histological differentiation.
Conclusion: Multiparametric MRI comprising DWI, BOLD, and DCE MRI is feasible for assessment of primary RCC. BOLD moderately correlates to DCE MRI-derived perfusion. ADC shows moderate correlation to the extracellular volume, but does not correlate to tumor oxygenation or perfusion. In this preliminary study DCE-MRI appeared superior to BOLD and DWI for histological differentiation.
(Copyright © 2013 AUR. Published by Elsevier Inc. All rights reserved.)
المشرفين على المادة: 0 (Contrast Media)
S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20130514 Date Completed: 20131104 Latest Revision: 20131121
رمز التحديث: 20221213
DOI: 10.1016/j.acra.2013.01.015
PMID: 23664397
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-4046
DOI:10.1016/j.acra.2013.01.015