دورية أكاديمية
أعرض في EDS

Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults.

التفاصيل البيبلوغرافية
العنوان: Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults.
المؤلفون: Neeland IJ; Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Ayers CR, Rohatgi AK, Turer AT, Berry JD, Das SR, Vega GL, Khera A, McGuire DK, Grundy SM, de Lemos JA
المصدر: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2013 Sep; Vol. 21 (9), pp. E439-47. Date of Electronic Publication: 2013 May 19.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2013- : Malden, MA : John Wiley & Sons
Original Publication: Silver Spring, MD : NAASO, the Obesity Society, c2006-
مواضيع طبية MeSH: Body Fat Distribution*, Atherosclerosis/*etiology , Heart Diseases/*etiology , Intra-Abdominal Fat/*pathology , Metabolic Syndrome/*etiology , Obesity/*complications , Subcutaneous Fat/*pathology, Adiponectin/blood ; Adult ; Atherosclerosis/blood ; Atherosclerosis/pathology ; Biomarkers/metabolism ; C-Reactive Protein/metabolism ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cholesterol, VLDL/blood ; Dyslipidemias/complications ; Female ; Heart Diseases/blood ; Heart Diseases/pathology ; Humans ; Inflammation/blood ; Inflammation Mediators/metabolism ; Insulin Resistance ; Intra-Abdominal Fat/metabolism ; Leptin/blood ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/pathology ; Middle Aged ; Multivariate Analysis ; Obesity/blood ; Obesity/metabolism ; Obesity/pathology ; Phenotype ; Subcutaneous Fat/metabolism
مستخلص: Objective: Visceral (VAT) and abdominal subcutaneous (SAT) adipose tissues contribute to obesity but may have different metabolic and atherosclerosis risk profiles. We sought to determine the associations of abdominal VAT and SAT mass with markers of cardiac and metabolic risk in a large, multiethnic, population-based cohort of obese adults.
Design and Methods: Among obese participants in the Dallas Heart Study, we examined the cross-sectional associations of abdominal VAT and SAT mass, assessed by magnetic resonance imaging (MRI) and indexed to body surface area (BSA), with circulating biomarkers of insulin resistance, dyslipidemia, and inflammation (n = 942); and with aortic plaque and liver fat by MRI and coronary calcium by computed tomography (n = 1200). Associations of VAT/BSA and SAT/BSA were examined after adjustment for age, sex, race, menopause, and body mass index.
Results: In multivariable models, VAT significantly associated with the homeostasis model assessment of insulin resistance (HOMA-IR), lower adiponectin, smaller LDL and HDL particle size, larger VLDL size, and increased LDL and VLDL particle number (p < 0.001 for each). VAT also associated with prevalent diabetes, metabolic syndrome, hepatic steatosis, and aortic plaque (p < 0.001 for each). VAT independently associated with C-reactive protein but not with any other inflammatory biomarkers tested. In contrast, SAT associated with leptin and inflammatory biomarkers, but not with dyslipidemia or atherosclerosis. Associations between SAT and HOMA-IR were significant in univariable analyses but attenuated after multivariable adjustment.
Conclusion: VAT associated with an adverse metabolic, dyslipidemic, and atherogenic obesity phenotype. In contrast, SAT demonstrated a more benign phenotype, characterized by modest associations with inflammatory biomarkers and leptin, but no independent association with dyslipidemia, insulin resistance, or atherosclerosis in obese individuals. These findings suggest that abdominal fat distribution defines distinct obesity sub-phenotypes with heterogeneous metabolic and atherosclerosis risk.
(Copyright © 2012 The Obesity Society.)
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معلومات مُعتمدة: UL1 TR001105 United States TR NCATS NIH HHS; UL1 TR000451 United States TR NCATS NIH HHS; M01 RR000633 United States RR NCRR NIH HHS; T32 HL007360 United States HL NHLBI NIH HHS; UL1DE019584 United States DE NIDCR NIH HHS; PL1DK081182 United States DK NIDDK NIH HHS; UL1TR000451 United States TR NCATS NIH HHS; T32HL007360 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (Adiponectin)
0 (Biomarkers)
0 (Cholesterol, HDL)
0 (Cholesterol, LDL)
0 (Cholesterol, VLDL)
0 (Inflammation Mediators)
0 (Leptin)
9007-41-4 (C-Reactive Protein)
تواريخ الأحداث: Date Created: 20130521 Date Completed: 20140422 Latest Revision: 20220318
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3751977
DOI: 10.1002/oby.20135
PMID: 23687099
قاعدة البيانات: MEDLINE
الوصف
تدمد:1930-739X
DOI:10.1002/oby.20135