دورية أكاديمية
[Association between APOBEC3G polymorphisms and susceptibility to chronic hepatitis B].
| العنوان: | [Association between APOBEC3G polymorphisms and susceptibility to chronic hepatitis B]. |
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| المؤلفون: | You Z; Department of Epidemiology, Southern Medical University, Guangzhou, China. zhiyiyou@126.com, Zhou F, Wang X, Chen C, Zhou J, Zhao D, Hu G |
| المصدر: | Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2013 May; Vol. 33 (5), pp. 769-71. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Nanfang yi ke da xue xue bao bian ji bu Country of Publication: China NLM ID: 101266132 Publication Model: Print Cited Medium: Print ISSN: 1673-4254 (Print) Linking ISSN: 16734254 NLM ISO Abbreviation: Nan Fang Yi Ke Da Xue Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Guangzhou : Nanfang yi ke da xue xue bao bian ji bu, 2005- |
| مواضيع طبية MeSH: | Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide*, Cytidine Deaminase/*genetics , Hepatitis B, Chronic/*genetics, APOBEC-3G Deaminase ; Adult ; Alleles ; Case-Control Studies ; Female ; Genotype ; Humans ; Male ; Young Adult |
| مستخلص: | Objective: To investigate the association between rs185983011 single-nucleotide polymorphisms (SNP) of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and the susceptibility to chronic hepatitis B. Methods: The blood samples were collected from 186 healthy subjects and 159 patients with chronic hepatitis B. The rs185983011 SNP was detected and genotyped by sequencing with Sanger's method to analyze the relationship between rs185983011 SNP and chronic hepatitis B. Results: Only C/C and C/T genotypes of the alleles of rs185983011 SNP were found in the tested subjects, and the C/C genotype was predominant (97.7%). The distribution frequencies of rs185983011 SNP genotypes and alleles showed no significant difference between healthy subjects and patients with chronic hepatitis B (P>0.05). Conclusion: The predominant genotype of rs185983011 SNP of APOBEC3G is C/C in the tested subjects, and rs185983011 SNP does not appear to associate with the susceptibility to chronic hepatitis B. |
| المشرفين على المادة: | EC 3.5.4.5 (APOBEC-3G Deaminase) EC 3.5.4.5 (APOBEC3G protein, human) EC 3.5.4.5 (Cytidine Deaminase) |
| تواريخ الأحداث: | Date Created: 20130522 Date Completed: 20140724 Latest Revision: 20161125 |
| رمز التحديث: | 20221213 |
| PMID: | 23689004 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1673-4254 |
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