دورية أكاديمية

The potential of helical tomotherapy in the treatment of head and neck cancer.

التفاصيل البيبلوغرافية
العنوان: The potential of helical tomotherapy in the treatment of head and neck cancer.
المؤلفون: Van Gestel D; Department of Radiotherapy, University Radiotherapy Antwerp, Antwerp, Belgium. dirk.vangestel@zna.be, Verellen D, Van De Voorde L, de Ost B, De Kerf G, Vanderveken O, Van Laer C, Van den Weyngaert D, Vermorken JB, Gregoire V
المصدر: The oncologist [Oncologist] 2013 Jun; Vol. 18 (6), pp. 697-706. Date of Electronic Publication: 2013 May 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9607837 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-490X (Electronic) Linking ISSN: 10837159 NLM ISO Abbreviation: Oncologist Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : Oxford : Oxford University Press
Original Publication: Dayton, Ohio : AlphaMed Press, c1996-
مواضيع طبية MeSH: Head and Neck Neoplasms/*radiotherapy , Radiotherapy, Image-Guided/*methods , Radiotherapy, Intensity-Modulated/*methods, Head and Neck Neoplasms/pathology ; Humans ; Radiotherapy Dosage ; Randomized Controlled Trials as Topic ; Tomography, X-Ray Computed
مستخلص: A decade after its first introduction into the clinic, little is known about the clinical impact of helical tomotherapy (HT) on head and neck cancer (HNC) treatment. Therefore, we analyzed the basics of this technique and reviewed the literature regarding HT's potential benefit in HNC. The past two decades have been characterized by a huge technological evolution in photon beam radiotherapy (RT). In HNC, static beam intensity-modulated radiotherapy (IMRT) has shown superiority over three-dimensional conformal RT in terms of xerostomia and is considered the standard of care. However, the next-generation IMRT, the rotational IMRT, has been introduced into the clinic without any evidence of superiority over static beam IMRT other than being substantially faster. Of these rotational techniques, HT is the first system especially developed for IMRT in combination with image-guided RT. HT is particularly promising for the treatment of HNC because its sharp dose gradients maximally spare the many radiosensitive organs at risk nearby. In addition, HT's integrated computed tomography scan assures a very precise dose administration and allows for some adaptive RT. Because HT is specifically developed for IMRT in combination with (integrated) image-guidance, it allows for precise dose distribution ("dose painting"), patient setup, and dose delivery. As such, it is an excellent tool for difficult HNC irradiation. The literature on the clinical results of HT in HNC all show excellent short-term (≤2 years) results with acceptable toxicity profiles. However, properly designed trials are still warranted to further substantiate these results.
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فهرسة مساهمة: Keywords: Head and neck cancer; Helical tomotherapy
تواريخ الأحداث: Date Created: 20130601 Date Completed: 20140213 Latest Revision: 20240321
رمز التحديث: 20240321
مُعرف محوري في PubMed: PMC4063397
DOI: 10.1634/theoncologist.2012-0424
PMID: 23723331
قاعدة البيانات: MEDLINE
الوصف
تدمد:1549-490X
DOI:10.1634/theoncologist.2012-0424