دورية أكاديمية
Wegener granulomatosis as an uncommon cause of panhypopituitarism in childhood.
| العنوان: | Wegener granulomatosis as an uncommon cause of panhypopituitarism in childhood. |
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| المؤلفون: | Kara O, Demirel F, Acar BC, Cakar N |
| المصدر: | Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2013; Vol. 26 (9-10), pp. 959-62. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 9508900 Publication Model: Print Cited Medium: Internet ISSN: 2191-0251 (Electronic) Linking ISSN: 0334018X NLM ISO Abbreviation: J Pediatr Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mar. 2011- : Berlin : Walter de Gruyter Original Publication: London : Freund Pub. House, [1995- |
| مواضيع طبية MeSH: | Granulomatosis with Polyangiitis/*physiopathology , Hypopituitarism/*etiology , Pituitary Gland/*physiopathology, Adolescent ; Antibodies, Antineutrophil Cytoplasmic/analysis ; Antineoplastic Agents, Alkylating/therapeutic use ; Arthralgia/etiology ; Arthralgia/prevention & control ; Cyclophosphamide/therapeutic use ; Drug Therapy, Combination ; Female ; Glucocorticoids/therapeutic use ; Granuloma/etiology ; Granuloma/prevention & control ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/drug therapy ; Granulomatosis with Polyangiitis/immunology ; Humans ; Myalgia/etiology ; Myalgia/prevention & control ; Oral Ulcer/etiology ; Oral Ulcer/prevention & control ; Pituitary Gland/immunology ; Pituitary Neoplasms/etiology ; Pituitary Neoplasms/prevention & control ; Proteinuria/etiology ; Proteinuria/prevention & control ; Sinusitis/etiology ; Sinusitis/prevention & control ; Treatment Outcome ; Tumor Burden/drug effects |
| مستخلص: | Wegener granulomatosis (WG) is a cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-associated, multi-system, necrotizing granulomatous vasculitis. Inflammation of the nasal or oral mucosa, and lung and kidney involvements are typical in the course of the disease. In rare cases, pituitary involvement may occur and cause panhypopituitarism. Pituitary involvement is very rare, and only two pediatric case reports have been published to date out of a total of 24 cases. This is a case report of an adolescent patient who presented with panhypopituitarism symptoms and was later diagnosed with WG. A 16-year-old female patient complained of fever, headache, purulent nasal discharge and severe muscle and joint pain. Additionally, she had polyuria and polydipsia. Investigations revealed a pituitary mass and panhypopituitarism. Positivity of c-ANCA and renal biopsy result compatible with WG confirmed the diagnosis. |
| المشرفين على المادة: | 0 (Antibodies, Antineutrophil Cytoplasmic) 0 (Antineoplastic Agents, Alkylating) 0 (Glucocorticoids) 8N3DW7272P (Cyclophosphamide) |
| SCR Disease Name: | Combined Pituitary Hormone Deficiency |
| تواريخ الأحداث: | Date Created: 20130605 Date Completed: 20140813 Latest Revision: 20141120 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1515/jpem-2013-0033 |
| PMID: | 23729544 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2191-0251 |
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| DOI: | 10.1515/jpem-2013-0033 |