دورية أكاديمية
أعرض في EDS

ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.

التفاصيل البيبلوغرافية
العنوان: ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.
المؤلفون: Arias-González L; Laboratorio de Oncología Molecular, Centro Regional de Investigaciones Biomédicas/University of Castilla la Mancha CRIB/UCLM, Albacete, Spain., Moreno-Gimeno I, del Campo AR, Serrano-Oviedo L, Valero ML, Esparís-Ogando A, de la Cruz-Morcillo MÁ, Melgar-Rojas P, García-Cano J, Cimas FJ, Hidalgo MJ, Prado A, Callejas-Valera JL, Nam-Cha SH, Giménez-Bachs JM, Salinas-Sánchez AS, Pandiella A, del Peso L, Sánchez-Prieto R
المصدر: Neoplasia (New York, N.Y.) [Neoplasia] 2013 Jun; Vol. 15 (6), pp. 649-59.
نوع المنشور: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : [Amsterdam] : Elsevier
Original Publication: New York, NY : Stockton Press, c1999-
مواضيع طبية MeSH: Carcinoma, Renal Cell/*metabolism , Kidney Neoplasms/*metabolism , Mitogen-Activated Protein Kinase 7/*metabolism , Von Hippel-Lindau Tumor Suppressor Protein/*metabolism, Adult ; Aged ; Animals ; Base Sequence ; COS Cells ; Carcinoma, Renal Cell/pathology ; Cell Line ; Cell Movement ; Chlorocebus aethiops ; Female ; Gene Knockdown Techniques ; Humans ; Hydroxylation ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Mitogen-Activated Protein Kinase 7/genetics ; Molecular Sequence Data ; Prognosis ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitin/metabolism ; Von Hippel-Lindau Tumor Suppressor Protein/genetics
مستخلص: Extracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein kinase (MAPK) 1, is implicated in a wide range of biologic processes, which include proliferation or vascularization. Here, we show that ERK5 is degraded through the ubiquitin-proteasome system, in a process mediated by the tumor suppressor von Hippel-Lindau (VHL) gene, through a prolyl hydroxylation-dependent mechanism. Our conclusions derive from transient transfection assays in Cos7 cells, as well as the study of endogenous ERK5 in different experimental systems such as MCF7, HMEC, or Caki-2 cell lines. In fact, the specific knockdown of ERK5 in pVHL-negative cell lines promotes a decrease in proliferation and migration, supporting the role of this MAPK in cellular transformation. Furthermore, in a short series of fresh samples from human clear cell renal cell carcinoma, high levels of ERK5 correlate with more aggressive and metastatic stages of the disease. Therefore, our results provide new biochemical data suggesting that ERK5 is a novel target of the tumor suppressor VHL, opening a new field of research on the role of ERK5 in renal carcinomas.
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المشرفين على المادة: 0 (Ubiquitin)
EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 7)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
EC 6.3.2.- (VHL protein, human)
تواريخ الأحداث: Date Created: 20130605 Date Completed: 20140106 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3664997
DOI: 10.1593/neo.121896
PMID: 23730213
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5586
DOI:10.1593/neo.121896