دورية أكاديمية
Somatic growth trajectory in the fetus with hypoplastic left heart syndrome.
| العنوان: | Somatic growth trajectory in the fetus with hypoplastic left heart syndrome. |
|---|---|
| المؤلفون: | Cnota JF; Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. james.cnota@cchmc.org, Hangge PT, Wang Y, Woo JG, Hinton AC, Divanovic AA, Michelfelder EC, Hinton RB |
| المصدر: | Pediatric research [Pediatr Res] 2013 Sep; Vol. 74 (3), pp. 284-9. Date of Electronic Publication: 2013 Jun 14. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : New York : Nature Publishing Group Original Publication: Basel ; New York : Karger. |
| مواضيع طبية MeSH: | Fetal Development/*physiology , Fetal Growth Retardation/*physiopathology , Hypoplastic Left Heart Syndrome/*physiopathology, Anthropometry ; Birth Weight ; Echocardiography ; Female ; Fetal Growth Retardation/etiology ; Humans ; Hypoplastic Left Heart Syndrome/complications ; Infant, Newborn ; Pregnancy ; Ultrasonography, Prenatal |
| مستخلص: | Background: Fetal growth abnormalities in hypoplastic left heart syndrome (HLHS) have been documented primarily by birth measurements. Fetal growth trajectory has not been described. We hypothesized that fetal growth trajectory declines across late gestation in this population. Methods: Infants with a prenatal diagnosis of HLHS and no history of prematurity or a genetic syndrome were identified. Fetal ultrasound measurements and birth anthropometrics were obtained from clinical records. z-Scores for estimated fetal weight (EFWz) and birth weight (BWTz) were compared. BWTz for three neonatal standards were compared. Results: Paired fetal and neonatal data were identified in 33 cases of HLHS. Mean gestational age at ultrasound and birth were 27 and 38 wk, respectively. BWTz was lower than EFWz by a mean of 0.82 (SD: 0.72, P < 0.0001), with 64% of subjects demonstrating a decrease in z-score of >0.5. Umbilical artery (UA) Doppler found no evidence of significant placental insufficiency. Modest differences in BWTz were seen across BWT standards in this cohort. Conclusion: The majority of fetuses with HLHS demonstrate decreased growth velocity during later pregnancy, suggesting growth abnormalities manifest in utero. The potential relationship to future clinical outcomes warrants further study. |
| معلومات مُعتمدة: | UL1 TR000077 United States TR NCATS NIH HHS; HL085122 United States HL NHLBI NIH HHS |
| تواريخ الأحداث: | Date Created: 20130618 Date Completed: 20140331 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1038/pr.2013.100 |
| PMID: | 23770922 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1530-0447 |
|---|---|
| DOI: | 10.1038/pr.2013.100 |