دورية أكاديمية
Assessment of circumferential angle-closure by the iris-trabecular contact index with swept-source optical coherence tomography.
| العنوان: | Assessment of circumferential angle-closure by the iris-trabecular contact index with swept-source optical coherence tomography. |
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| المؤلفون: | Baskaran M; Singapore National Eye Centre, Singapore and Singapore Eye Research Institute, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ho SW, Tun TA, How AC, Perera SA, Friedman DS, Aung T |
| المصدر: | Ophthalmology [Ophthalmology] 2013 Nov; Vol. 120 (11), pp. 2226-31. Date of Electronic Publication: 2013 Jun 14. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 7802443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-4713 (Electronic) Linking ISSN: 01616420 NLM ISO Abbreviation: Ophthalmology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : New York : Elsevier Original Publication: Rochester, Minn., American Academy of Ophthalmology. |
| مواضيع طبية MeSH: | Glaucoma, Angle-Closure/*diagnosis , Iris/*pathology , Tomography, Optical Coherence/*methods , Trabecular Meshwork/*pathology, Anterior Chamber/pathology ; Area Under Curve ; Female ; Gonioscopy ; Humans ; Imaging, Three-Dimensional ; Intraocular Pressure ; Male ; Middle Aged ; Prospective Studies ; Tissue Adhesions ; Tonometry, Ocular |
| مستخلص: | Purpose: To evaluate the diagnostic performance of the iris-trabecular contact (ITC) index, a measure of the degree of angle-closure, using swept-source optical coherence tomography (SSOCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) in comparison with gonioscopy. Design: Prospective observational study. Participants: A total of 108 normal subjects and 32 subjects with angle-closure. Methods: The SSOCT 3-dimensional angle scans, which obtain radial scans for the entire circumference of the angle, were performed under dark conditions and analyzed using customized software by a single examiner masked to the subjects' clinical details. The ITC index was calculated as a percentage of the angle that was closed on SSOCT images. First-order agreement coefficient (AC1) statistics and area under the receiver operating characteristic curve (AUC) analyses were performed for angle-closure on the basis of the ITC index in comparison with gonioscopy. Main Outcome Measures: Angle-closure on gonioscopy was defined as nonvisibility of posterior trabecular meshwork for at least 2 quadrants. Agreement of the ITC index with gonioscopically defined angle-closure was assessed using the AC1 statistic. Results: Study subjects were predominantly Chinese (95.7%) and female (70.7%), with a mean age of 59.2 (standard deviation, 8.9) years. The median ITC index was 15.24% for gonioscopically open-angle eyes (n = 108) and 48.5% for closed-angle eyes (n = 32) (P = 0.0001). The agreement for angle-closure based on ITC index cutoffs (>35% and ≥50%) and gonioscopic angle-closure was 0.699 and 0.718, respectively. The AUC for angle-closure detection using the ITC index was 0.83 (95% confidence interval, 0.76-0.89), with an ITC index >35% having a sensitivity of 71.9% and specificity of 84.3%. Conclusions: The ITC index is a summary measure of the circumferential extent of angle-closure as imaged with SSOCT. The index had moderate agreement and good diagnostic performance for angle-closure with gonioscopy as the reference standard. (Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20130619 Date Completed: 20140110 Latest Revision: 20131104 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ophtha.2013.04.020 |
| PMID: | 23774103 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1549-4713 |
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| DOI: | 10.1016/j.ophtha.2013.04.020 |