دورية أكاديمية
أعرض في EDS

Identification of four novel Rhipicephalus annulatus upregulated salivary gland proteins as candidate vaccines.

التفاصيل البيبلوغرافية
العنوان: Identification of four novel Rhipicephalus annulatus upregulated salivary gland proteins as candidate vaccines.
المؤلفون: Shahein YE; Molecular Biology Department, National Research Centre, Dokki, Cairo, Egypt. yassershahein_nrc@yahoo.com, Abouelella AM, Hussein NA, Hamed RR, El-Hakim AE, Abdel-Shafy S, Tork SE
المصدر: The protein journal [Protein J] 2013 Jun; Vol. 32 (5), pp. 392-8.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 101212092 Publication Model: Print Cited Medium: Internet ISSN: 1875-8355 (Electronic) Linking ISSN: 15723887 NLM ISO Abbreviation: Protein J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Dordrecht : Springer
Original Publication: Dordrecht, The Netherlands ; New York : Kluwer Academic/Plenum, c2004-
مواضيع طبية MeSH: Arthropod Proteins/*genetics , Cattle Diseases/*parasitology , Rhipicephalus/*genetics , Salivary Proteins and Peptides/*genetics , Tick Infestations/*veterinary, Amino Acid Sequence ; Animals ; Arthropod Proteins/chemistry ; Arthropod Proteins/immunology ; Cattle ; Cattle Diseases/prevention & control ; Molecular Sequence Data ; Phylogeny ; Rabbits ; Rhipicephalus/chemistry ; Rhipicephalus/classification ; Rhipicephalus/immunology ; Salivary Proteins and Peptides/chemistry ; Salivary Proteins and Peptides/immunology ; Sequence Alignment ; Tick Infestations/parasitology ; Tick Infestations/prevention & control ; Up-Regulation ; Vaccines/chemistry ; Vaccines/genetics ; Vaccines/immunology
مستخلص: The control of Rhipicephalus annulatus ticks in Egypt and other countries relies principally on the application of acaricides which have many drawbacks. Recently, cattle vaccination against ticks showed a potential unconventional approach to control ticks. As a target, salivary glands contain various proteins that may play specific roles during attachment, feeding and may modulate the immune system of the host. We have performed immunoscreening on expression normalized cDNA library to identify unique R. annulatus proteins from salivary gland (RaSal) that are particularly expressed during engorgement. We also present the cloning and sequencing of four novel cDNAs (RaSal1-4) from salivary glands that are expressed during feeding. RaSal4 shows 13 cysteine amino acid residues forming 6 potential disulfide bonds. We detected the expression level of the four genes during embryogenesis in eggs collected at 6, 12 and 18 days after oviposition. RT-PCR analysis detected these proteins at days 12 and 18 while slight amplification was detected at day 6 for only RaSal2. The expression of these salivary genes may put forward new vaccines to control tick infestations and tick-borne diseases.
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المشرفين على المادة: 0 (Arthropod Proteins)
0 (Salivary Proteins and Peptides)
0 (Vaccines)
تواريخ الأحداث: Date Created: 20130619 Date Completed: 20140117 Latest Revision: 20211021
رمز التحديث: 20231215
DOI: 10.1007/s10930-013-9498-x
PMID: 23775170
قاعدة البيانات: MEDLINE
الوصف
تدمد:1875-8355
DOI:10.1007/s10930-013-9498-x