دورية أكاديمية
Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccines.
العنوان: | Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccines. |
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المؤلفون: | Sheehy SH; The Jenner Institute; University of Oxford; Oxford, UK., Douglas AD, Draper SJ |
المصدر: | Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2013 Sep; Vol. 9 (9), pp. 1831-40. Date of Electronic Publication: 2013 Jun 18. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, Tex. : Landes Bioscience |
مواضيع طبية MeSH: | Biomedical Research/*methods , Malaria Vaccines/*immunology , Malaria, Falciparum/*immunology , Malaria, Falciparum/*prevention & control , Plasmodium falciparum/*immunology, Humans ; Malaria Vaccines/administration & dosage |
مستخلص: | In the absence of any highly effective vaccine candidate against Plasmodium falciparum malaria, it remains imperative for the field to pursue all avenues that may lead to the successful development of such a formulation. The development of a subunit vaccine targeting the asexual blood-stage of Plasmodium falciparum malaria infection has proven particularly challenging with only limited success to date in clinical trials. However, only a fraction of potential blood-stage vaccine antigens have been evaluated as targets, and a number of new promising candidate antigen formulations and delivery platforms are approaching clinical development. It is therefore essential that reliable and sensitive methods of detecting, or ruling out, even modest efficacy of blood-stage vaccines in small clinical trials be established. In this article we evaluate the challenges facing blood-stage vaccine developers, assess the appropriateness and limitations of various in vivo approaches for efficacy assessment and suggest future directions for the field. |
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معلومات مُعتمدة: | G0700735 United Kingdom MRC_ Medical Research Council; G1000527 United Kingdom MRC_ Medical Research Council; 089455/2/09/Z United Kingdom WT_ Wellcome Trust; 097940/Z/11/Z United Kingdom WT_ Wellcome Trust |
فهرسة مساهمة: | Keywords: clinical; efficacy; falciparum; malaria; vaccine |
المشرفين على المادة: | 0 (Malaria Vaccines) |
تواريخ الأحداث: | Date Created: 20130620 Date Completed: 20140729 Latest Revision: 20220129 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3906345 |
DOI: | 10.4161/hv.25383 |
PMID: | 23778312 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2164-554X |
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DOI: | 10.4161/hv.25383 |