دورية أكاديمية
Properties, metabolisms, and applications of (L)-proline analogues.
| العنوان: | Properties, metabolisms, and applications of (L)-proline analogues. |
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| المؤلفون: | Bach TM; Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Vietnam., Takagi H |
| المصدر: | Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2013 Aug; Vol. 97 (15), pp. 6623-34. Date of Electronic Publication: 2013 Jun 19. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0614 (Electronic) Linking ISSN: 01757598 NLM ISO Abbreviation: Appl Microbiol Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer International, c1984- |
| مواضيع طبية MeSH: | Proline/*metabolism , Proline/*pharmacology, Azetidinecarboxylic Acid/metabolism ; Azetidinecarboxylic Acid/pharmacology ; Biotransformation ; Proline/analogs & derivatives |
| مستخلص: | Due to the unique role of L-proline in the folding and structure of protein, a variety of synthetic proline analogues have been developed. L-Proline analogues have been proven to be valuable reagents for studying cellular metabolism and the regulation of macromolecule synthesis in both prokaryotic and eukaryotic cells. In addition to these fundamental researches, they are useful compounds for industrial use. For instance, microorganisms that overproduce L-proline have been obtained by isolating mutants resistant to L-proline analogues. They are also promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occurring or de novo designed peptides. Among L-proline analogues, L-azetidine-2-carboxylic acid (L-AZC) is a toxic non-proteinogenic amino acid originally found in lily of the valley plants and trans-4-hydroxy-L-proline (4-L-THOP) is the most abundant component of mammalian collagen. Many hydroxyprolines (HOPs), such as 4-L-THOP and cis-4-hydroxy-L-proline (4-L-CHOP), are useful chiral building blocks for the organic synthesis of pharmaceuticals. In addition, L-AZC and 4-L-CHOP, which are potent inhibitors of cell growth, have been tested for their antitumor activity in tissue culture and in vivo. In this review, we describe the recent discoveries regarding the physiological properties and microbial production and metabolism of L-proline analogues, particularly L-AZC and HOPs. Their applications in fundamental research and industrial use are also discussed. |
| المشرفين على المادة: | 5GZ3E0L9ZU (Azetidinecarboxylic Acid) 9DLQ4CIU6V (Proline) |
| تواريخ الأحداث: | Date Created: 20130620 Date Completed: 20131029 Latest Revision: 20181203 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s00253-013-5022-7 |
| PMID: | 23780584 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-0614 |
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| DOI: | 10.1007/s00253-013-5022-7 |