دورية أكاديمية
[Late-replicating regions in salivary gland polytene chromosomes of Drosophila melanogaster].
| العنوان: | [Late-replicating regions in salivary gland polytene chromosomes of Drosophila melanogaster]. |
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| المؤلفون: | Kolesnikov TD, Andreenkova NG, Beliaeva ES, Goncharov FP, Zykova TIu, Boldyreva LV, Pokholkova gV, Zhimulev IF |
| المصدر: | Tsitologiia [Tsitologiia] 2013; Vol. 55 (3), pp. 178-80. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Rossiiskaia Akademiia Nauk Country of Publication: Russia (Federation) NLM ID: 0417363 Publication Model: Print Cited Medium: Print ISSN: 0041-3771 (Print) Linking ISSN: 00413771 NLM ISO Abbreviation: Tsitologiia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Rossiiskaia Akademiia Nauk Original Publication: Moskva, Akademiia nauk SSSR. |
| مواضيع طبية MeSH: | DNA Replication/*genetics , Drosophila melanogaster/*genetics , Heterochromatin/*genetics , Polytene Chromosomes/*genetics, Animals ; DNA-Binding Proteins ; Salivary Glands/cytology |
| مستخلص: | About 240 specific regions that are replicated at the very end of the S-phase have been identified in D. melanogaster polytene chromosomes. These regions have a repressive chromatine state, low gene density, long intergenic distances and are enriched in tissue specific genes. In polytene chromosomes, about a quarter of these regions have no enough time to complete replication. As a result, underreplication zones represented by fewer DNA copy number, appear. We studied 60 chromosome regions that demonstrated the most pronounced under-replication. By comparing the location of these regions on a molecular map with syntenic blocks found earlier for Drosophila species by von Grotthuss et al., 2010, we have shown that across the genus Drosophila, these regions tend to have conserved gene order. This forces us to assume the existence of evolutionary mechanisms aimed at maintaining the integrity of these regions. |
| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (Heterochromatin) |
| تواريخ الأحداث: | Date Created: 20130626 Date Completed: 20130712 Latest Revision: 20130625 |
| رمز التحديث: | 20221213 |
| PMID: | 23795461 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0041-3771 |
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