دورية أكاديمية
[Relationship between XRCC3 gene polymorphism and susceptibility to lead poisoning in male lead-exposed workers].
| العنوان: | [Relationship between XRCC3 gene polymorphism and susceptibility to lead poisoning in male lead-exposed workers]. |
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| المؤلفون: | Liu XQ; Department of Occupational Health, Fuzhou City Center for Disease Control and Prevention, Fujian China., Zhang Z |
| المصدر: | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases [Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi] 2013 Jun; Vol. 31 (6), pp. 401-4. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Tianjin shi lao dong wei sheng yan jiu suo ; Tianjin shi lao dong wei sheng huan jing yi xue hui Country of Publication: China NLM ID: 8410840 Publication Model: Print Cited Medium: Print ISSN: 1001-9391 (Print) Linking ISSN: 10019391 NLM ISO Abbreviation: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Tientsin] : Tianjin shi lao dong wei sheng yan jiu suo ; Tianjin shi lao dong wei sheng huan jing yi xue hui, [1983- |
| مواضيع طبية MeSH: | Polymorphism, Genetic*, DNA-Binding Proteins/*genetics , Lead Poisoning/*genetics , Occupational Diseases/*genetics, Adult ; Genetic Predisposition to Disease ; Genotype ; Humans ; Lead/blood ; Male ; Young Adult |
| مستخلص: | Objective: To investigate the relationship between genetic polymorphism of X-ray repair cross-complementing gene 3 (XRCC3) and susceptibility to lead poisoning in male lead-exposed workers. Methods: Peripheral venous blood and morning urine samples were collected from 326 male lead-exposed workers in a storage battery factory in Fuzhou. Blood lead, urine lead, blood zinc protoporphyrin (ZPP), blood calcium, and blood iron were measured. The genotype of XRCC3 was determined by polymerase chain reaction-restriction fragment length polymorphism method. The relationship between XRCC3 gene polymorphism and susceptibility to lead poisoning in male lead-exposed workers was analyzed. Results: Genetic polymorphism of XRCC3 was seen in the 326 subjects. The frequency distribution of XRCC3 genotypes, XRCC3-241CC (wild type), XRCC3-241CT (heterozygous mutation), and XRCC3-241TT (homozygous mutation), was in accordance with the Hardy-Weinberg equilibrium (P > 0.05). There were no significant differences in urine lead, blood ZPP, blood calcium, and blood iron between the lead-exposed workers with different XRCC3 genotypes (P > 0.05). The workers with XRCC3-241CT/TT had a significantly higher mean blood lead level than those with XRCC3-241CC (P < 0.05). With a blood lead level of 1.90 µmol/L as the cutoff value, the chi-square test and logistic regression analysis showed that the proportion of workers with XRCC3-241CT/TT was significantly higher than that of workers with XRCC3-241CC in the subjects with high blood leads (P < 0.05) and that the risk of high blood lead was significantly higher in the workers with XRCC3-241CT/TT than in those with XRCC3-241CC (OR = 2.34, 95%CI = 1.61 ∼ 5.13); the multivariate linear regression analysis showed that the workers with XRCC3-241CT/TT had high blood lead levels (β = 0.116, P < 0.05), the workers with smoking habit demonstrated marked lead absorption (β = 0.188, P < 0.05), good individual protection could reduce lead absorption (β = -0.247, P < 0.05), and the individuals with low serum Ca²⁺ levels had high blood lead levels (β = -0.145, P < 0.05). Conclusion: When exposed to the same level of lead at workplace, the workers with XRCC3-241CT/TT have a significantly higher blood lead level than those with XRCC3-241CC, so the genotype of XRCC3-241CT/TT accounts for higher susceptibility to lead poisoning. |
| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (X-ray repair cross complementing protein 3) 2P299V784P (Lead) |
| تواريخ الأحداث: | Date Created: 20130628 Date Completed: 20141030 Latest Revision: 20130627 |
| رمز التحديث: | 20240628 |
| PMID: | 23803535 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-9391 |
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