دورية أكاديمية
أعرض في EDS

Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery.

التفاصيل البيبلوغرافية
العنوان: Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery.
المؤلفون: Zhang Y; David H. Koch Institute for Integrative, Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA., Pelet JM, Heller DA, Dong Y, Chen D, Gu Z, Joseph BJ, Wallas J, Anderson DG
المصدر: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2013 Sep 06; Vol. 25 (33), pp. 4641-5. Date of Electronic Publication: 2013 Jun 27.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE
أسماء مطبوعة: Publication: Sept. 3, 1997- : Weinheim : Wiley-VCH
Original Publication: Deerfield Beach, FL : VCH Publishers, 1989-
مواضيع طبية MeSH: Gene Transfer Techniques*, Aminoglycosides/*chemistry , Lipids/*chemistry , RNA, Small Interfering/*metabolism, Animals ; HeLa Cells ; Humans ; Mice ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics
مستخلص: Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude.
(Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
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معلومات مُعتمدة: R01 CA132091 United States CA NCI NIH HHS; P30 CA014051 United States CA NCI NIH HHS; R37 EB000244 United States EB NIBIB NIH HHS; EB000244 United States EB NIBIB NIH HHS; 1-R01-CA132091-03 United States CA NCI NIH HHS; R01 EB000244 United States EB NIBIB NIH HHS
فهرسة مساهمة: Keywords: aminoglycoside; drug delivery; gene knockdown; nanoparticle; siRNA
المشرفين على المادة: 0 (Aminoglycosides)
0 (Lipids)
0 (RNA, Small Interfering)
تواريخ الأحداث: Date Created: 20130702 Date Completed: 20140501 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3898629
DOI: 10.1002/adma.201301917
PMID: 23813808
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4095
DOI:10.1002/adma.201301917