دورية أكاديمية
أعرض في EDS

Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.

التفاصيل البيبلوغرافية
العنوان: Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.
المؤلفون: Ekouevi DK; Université Bordeaux Segalen, ISPED, Centre INSERM U897- Epidémiologie-Biostatistique, Bordeaux, France ; Programme PACCI, Abidjan, Côte d'Ivoire ; Département des Sciences Fondamentales et Santé Publique, Université de Lomé, Lomé, Togo., Balestre E, Coffie PA, Minta D, Messou E, Sawadogo A, Minga A, Sow PS, Bissagnene E, Eholie SP, Gottlieb GS, Dabis F, Zannou DM, Ahouada C, Akakpo J, Ahomadegbé C, Bashi J, Gougounon-Houéto A, Azon-Kouanou A, Houngbé F, Koumakpaï S, Alihonou F, d'Almeida M, Hodonou I, Hounhoui G, Sagbo G, Tossa-Bagnan L, Adjide H, Drabo J, Bognounou R, Dienderé A, Traore E, Zoungrana L, Zerbo B, Sawadogo AB, Zoungrana J, Héma A, Soré I, Bado G, Tapsoba A, Yé D, Kouéta F, Ouedraogo S, Ouédraogo R, Hiembo W, Gansonré M, Messou E, Gnokoro JC, Koné M, Kouakou GM, Bosse CA, Brou K, Assi AI, Chenal H, Hawerlander D, Soppi F, Minga A, Abo Y, Bomisso G, Eholié SP, Amego MD, Andavi V, Diallo Z, Ello F, Tanon AK, Koule SO, Anzan KC, Guehi C, Aka EA, Issouf KL, Kouakou JC, N'gbeche MS, Touré P, Avit-Edi D, Kouakou K, Moh M, Yao VA, Folquet MA, Dainguy ME, Kouakou C, Méa-Assande VT, Oka-Berete G, Zobo N, Acquah P, Kokora MB, Eboua TF, Timité-Konan M, Ahoussou LD, Assouan JK, Sami MF, Kouadio C, Renner L, Goka B, Welbeck J, Sackey A, Owiafe SN, Wejse C, Silva ZJ, Paulo J, Rodrigues A, da Silva D, Medina C, Oliviera-Souto I, Ostergaard L, Laursen A, Sodemann M, Aaby P, Fomsgaard A, Erikstrup C, Eugen-Olsen J, Maïga MY, Diakité FF, Kalle A, Katile D, Traore HA, Minta D, Cissé T, Dembelé M, Doumbia M, Fomba M, Kaya AS, Traoré AM, Traoré H, Toure AA, Dicko F, Sylla M, Berthé A, Traoré HC, Koïta A, Koné N, N'diaye C, Coulibaly ST, Traoré M, Traoré N, Charurat M, Ajayi S, Dapiap S, Otu, Igbinoba F, Benson O, Adebamowo C, James J, Obaseki, Osakede P, Olasode J, Sow PS, Diop B, Manga NM, Tine JM, Signate Sy H, Ba A, Diagne A, Dior H, Faye M, Gueye RD, Mbaye AD, Patassi A, Kotosso A, Kariyare BG, Gbadamassi G, Komi A, Mensah-Zukong KE, Pakpame P, Lawson-Evi AK, Atakouma Y, Takassi E, Djeha A, Ephoévi-Gah A, Djibril Sel-H, Dabis F, Bissagnene E, Arrivé E, Coffie P, Ekouevi D, Jaquet A, Leroy V, Lewden C, Sasco A, Azani JC, Allou G, Balestre E, Bohossou F, Karcher S, Gonsan JM, Carrou JL, Lenaud S, Nchot C, Malateste K, Yao AR, Siloué B, Clouet G, Djetouan H, Doring A, Kouakou A, Rabourdin E, Rivenc J, Anglaret X, Ba B, Essanin JB, Ciaranello A, Datté S, Desmonde S, Diby JS, Gottlieb GS, Horo AG, Kangah SN, Malvy D, Meless D, Mounkaila-Harouna A, Ndondoki C, Shiboski C, Thiébaut R, Pac-Ci, Abidjan
مؤلفون مشاركون: IeDEA West Africa collaboration
المصدر: PloS one [PLoS One] 2013 Jun 18; Vol. 8 (6), pp. e66135. Date of Electronic Publication: 2013 Jun 18 (Print Publication: 2013).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Anti-HIV Agents/*therapeutic use , HIV Infections/*drug therapy , HIV-1/*isolation & purification , HIV-2/*isolation & purification, Adult ; Africa, Western/epidemiology ; Cohort Studies ; Female ; HIV Infections/virology ; Humans ; Male ; Middle Aged
مستخلص: Background: HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA).
Methods: We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region.
Results: Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7) and 42.4 years, IQR (37.0-47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm(3), IQR (83-247) among HIV-2 infected patients and 146 cells/mm(3), IQR (55-249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3) after 24 months on ART for HIV-2 patients and 169 cells/mm(3) for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3).
Conclusions: This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population.
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معلومات مُعتمدة: R01 AI060466 United States AI NIAID NIH HHS; U01 AI069919 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Anti-HIV Agents)
تواريخ الأحداث: Date Created: 20130705 Date Completed: 20171013 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3688850
DOI: 10.1371/journal.pone.0066135
PMID: 23824279
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0066135