دورية أكاديمية
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An update of animal models of Alzheimer disease with a reevaluation of plaque depositions.

التفاصيل البيبلوغرافية
العنوان: An update of animal models of Alzheimer disease with a reevaluation of plaque depositions.
المؤلفون: Lee JE; Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul 120-750, Korea., Han PL
المصدر: Experimental neurobiology [Exp Neurobiol] 2013 Jun; Vol. 22 (2), pp. 84-95. Date of Electronic Publication: 2013 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Korean Society for Brain and Neural Science Country of Publication: Korea (South) NLM ID: 101278187 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1226-2560 (Print) Linking ISSN: 12262560 NLM ISO Abbreviation: Exp Neurobiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Seoul, Korea : Korean Society for Brain and Neural Science, 1992-
مستخلص: Animal models of Alzheimer disease (AD) are used to study the mechanisms underlying AD pathogenesis, genetic interactions with genes of interest, and environmental risk factors that cause sporadic AD as well as to test the therapeutic effects of AD drug-candidates on neuropathology and cognitive function. To attain a comparative view on the AD models developed, representative AD lines were selected and summarized with respect to transgenic constructs and AD-related pathology. In addition, age-dependent plaque deposition data available in the literature for six representative AD models such as Tg2576, PDAPP, TgAPP23, Tg-APPswe/PS1dE9, 3xTg-AD, and 5XFAD mice were reevaluated using a photographic plaque reference scale method that was introduced recently. Tg2576, PDAPP, and TgAPP23 mice, which carry the amyloid precursor protein (APP) transgene, produced initially slow, but progressively accelerated plaque deposition as they aged, resulting in logistic plaque deposition. In contrast, Tg-APPswe/PS1dE9 and 3xTg-AD mice, which carry both APP and PS1 transgenes, developed abruptly accelerated plaque formation from the beginning, resulting in logarithmic plaque deposition. 5XFAD mice, which also carry both the APP and PS1 transgenes, developed a logarithmic deposition beginning at 2 months. This comparative analysis suggests that AD models may be classified into two distinct plaque deposition groups, and that early plaque models such as APPswe/PS1dE9, 3xTg-AD and 5XFAD might be useful to study the biochemical aspects of APP metabolism, whereas late plaque models such as Tg2576, PDAPP, and TgAPP23 might be useful to study more physiological and environmental aspects of AD pathogenesis, which occur on a longer time scale.
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فهرسة مساهمة: Keywords: APP and PS1 models; APP models; Alzheimer disease; comparison of plaque levels; plaque deposition
تواريخ الأحداث: Date Created: 20130709 Date Completed: 20130708 Latest Revision: 20231104
رمز التحديث: 20231104
مُعرف محوري في PubMed: PMC3699678
DOI: 10.5607/en.2013.22.2.84
PMID: 23833557
قاعدة البيانات: MEDLINE
الوصف
تدمد:1226-2560
DOI:10.5607/en.2013.22.2.84