دورية أكاديمية
Determining lectin specificity from glycan array data using motif segregation and GlycoSearch software.
| العنوان: | Determining lectin specificity from glycan array data using motif segregation and GlycoSearch software. |
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| المؤلفون: | Kletter D; Palo Alto Research Center, Palo Alto, California, USA., Cao Z, Bern M, Haab B |
| المصدر: | Current protocols in chemical biology [Curr Protoc Chem Biol] 2013; Vol. 5 (2), pp. 157-69. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101559235 Publication Model: Print Cited Medium: Internet ISSN: 2160-4762 (Electronic) Linking ISSN: 21604762 NLM ISO Abbreviation: Curr Protoc Chem Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : John Wiley & Sons, Inc. |
| مواضيع طبية MeSH: | Software*, Lectins/*chemistry , Polysaccharides/*chemistry, Binding Sites ; Plant Lectins/chemistry ; Protein Array Analysis/methods ; Substrate Specificity |
| مستخلص: | The glycan array is a powerful tool for investigating the specificities of glycan-binding proteins. By incubating a glycan-binding protein on a glycan array, the relative binding to hundreds of different oligosaccharides can be quantified in parallel. Based on these data, much information can be obtained about the preference of a glycan-binding protein for specific subcomponents of oligosaccharides, or motifs. In many cases, the analysis and interpretation of glycan array data can be time consuming and imprecise if done manually. Recently, GlycoSearch software was developed to facilitate the analysis and interpretation of glycan array data based on two previously developed methods, Motif Segregation and Outlier Motif Analysis. Here, the principles behind this method and the use of this new tool for mining glycan array data are described. The automated, objective, and precise analysis of glycan array data should enhance the value of these data for a broad range of research applications. (© 2013 by John Wiley & Sons, Inc.) |
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| معلومات مُعتمدة: | U01 CA152653 United States CA NCI NIH HHS; U01 CA168896 United States CA NCI NIH HHS; 1U01CA168896 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: glycan array; glycan motif; glycobiology; lectin |
| المشرفين على المادة: | 0 (Bauhinia purpurea lectin) 0 (Lectins) 0 (Plant Lectins) 0 (Polysaccharides) |
| تواريخ الأحداث: | Date Created: 20130711 Date Completed: 20150406 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4041489 |
| DOI: | 10.1002/9780470559277.ch130028 |
| PMID: | 23839995 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2160-4762 |
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| DOI: | 10.1002/9780470559277.ch130028 |